Cytogenetic and genotoxic effects of the insecticides, imidacloprid and methamidophos

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dc.contributor.authorKarabay N.U.
dc.contributor.authorOguz M.G.
dc.date.accessioned2019-10-27T00:10:17Z
dc.date.available2019-10-27T00:10:17Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractWe examined the cytogenetic and genotoxic effects of the neonicotinoid insecticide imidacloprid and the organophosphate insecticide methamidophos, when administered alone or in combination. These insecticides were tested with the bone marrow chromosome aberration assay and micronucleus test in rats and by the bacterial mutation assay (Salmonella/microsome mutagenicity assay). Wistar albino rats were orally fed daily with laboratory chow treated with various concentrations of insecticides, 50 and 100 mg/kg imidacloprid, 2.5 and 5 mg/kg methamidophos, and 2.5 and 5 mg/kg imidacloprid plus methamidophos, respectively, for 90 days. Numerical and structural chromosomal aberrations were evaluated. Significant differences were detected between all the insecticide-administered groups versus the control group and between the two concentrations of the pesticide-treated groups. Both concentrations of the insecticides induced a dose-related increase in the micronucleus frequency (P < 0.05). Dose-related increases in the number of revertants were observed with the two Salmonella strains (TA98 and TA100). All tested doses of the insecticides demonstrated mutagenic activity in the presence of S9 mix. These results lead us to the conclusion that the synergistic effect of methamidophos and imidacloprid causes an increase in potential damage to non-target organisms. ©FUNPEC-RP.en_US
dc.identifier.endpage662en_US
dc.identifier.issn1676-5680
dc.identifier.issue4en_US
dc.identifier.pmid16475109en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://hdl.handle.net/11454/21924
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofGenetics and Molecular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosome aberrationen_US
dc.subjectImidaclopriden_US
dc.subjectMethamidophosen_US
dc.subjectMicronucleusen_US
dc.subjectRaten_US
dc.subjectSalmonella microsome assayen_US
dc.titleCytogenetic and genotoxic effects of the insecticides, imidacloprid and methamidophosen_US
dc.typeArticleen_US

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