Sleep and cardiometabolic comorbidities in the obstructive sleep apnoea-COPD overlap syndrome: data from the European Sleep Apnoea Database

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dc.authoridVerbraecken, Johan/0000-0002-6087-678X
dc.authoridMcNicholas, Walter/0000-0001-5927-2738
dc.authoridBonsignore, Maria R/0000-0002-4875-7796
dc.authorwosidBonsignore, Maria R/U-6440-2017
dc.contributor.authorVan Zeller, Mafalda
dc.contributor.authorBaşoğlu, özen K.
dc.contributor.authorVerbraecken, Johan
dc.contributor.authorLombardi, Carolina
dc.contributor.authorMcNicholas, Walter T.
dc.contributor.authorPepin, Jean-Louis
dc.contributor.authorSteiropoulos, Paschalis
dc.date.accessioned2024-08-25T18:53:00Z
dc.date.available2024-08-25T18:53:00Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAim The impact of obstructive sleep apnoea (OSA)-COPD overlap syndrome (OVS) on sleep quality and cardiovascular outcomes has not been fully explored. We aimed to compare clinical and polysomnographic characteristics of patients with OVS versus patients with OSA, and to explore pathophysiological links between OVS and comorbidities. Study design and methods This cross-sectional analysis initially included data from 5600 patients with OSA and lung function in the European Sleep Apnoea Database. Two subgroups of patients with OSA (n=1018) or OVS (n=509) were matched (2:1) based on sex, age, body mass index and apnoea-hypopnea index at baseline. Results After matching, patients with OVS had more severe hypoxia, lower sleep efficiency and presented with higher prevalences of arterial hypertension, ischaemic heart disease and heart failure compared with patients with OSA. OVS was associated with a significant decrease in sleep efficiency (mean difference (beta) -3.0%, 95% CI -4.7 to -1.3) and in nocturnal mean peripheral oxyhaemoglobin saturation (S-pO2) (beta -1.1%, 95% CI -1.5 to -0.7). Further analysis revealed that a decrease in forced expiratory volume in 1 s and arterial oxygen tension was related to a decrease in sleep efficiency and in mean nocturnal S-pO2. A COPD diagnosis increased the odds of having heart failure by 1.75 (95% CI 1.15-2.67) and systemic hypertension by 1.36 (95% CI 1.07-1.73). Nocturnal hypoxia was strongly associated with comorbidities; the mean nocturnal S-pO2 and T90 (increase in time below S-pO2 of 90%) were associated with increased odds of systemic hypertension, diabetes and heart failure but the oxygen desaturation index was only related to hypertension and diabetes. Conclusion Patients with OVS presented with more sleep-related hypoxia, a reduced sleep quality and a higher risk for heart failure and hypertension.en_US
dc.description.sponsorshipRespironics Foundation; Bayer AG; Resmed Foundationen_US
dc.description.sponsorshipThe ESADA study group received unrestricted funding grants from the Respironics and Resmed Foundations, and an unrestricted collaboration grant from Bayer AG.en_US
dc.identifier.doi10.1183/23120541.00676-2022
dc.identifier.issn2312-0541
dc.identifier.issue3en_US
dc.identifier.pmid37483278en_US
dc.identifier.urihttps://doi.org/10.1183/23120541.00676-2022
dc.identifier.urihttps://hdl.handle.net/11454/102921
dc.identifier.volume9en_US
dc.identifier.wosWOS:001019024600012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEuropean Respiratory Soc Journals Ltden_US
dc.relation.ispartofErj Open Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectPulmonary-Diseaseen_US
dc.subjectQualityen_US
dc.subjectPopulationen_US
dc.titleSleep and cardiometabolic comorbidities in the obstructive sleep apnoea-COPD overlap syndrome: data from the European Sleep Apnoea Databaseen_US
dc.typeArticleen_US

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