Efficacy of Fractionated Plasma Separation and Adsorption System (Prometheus) for Treatment of Liver Failure Due to Mushroom Poisoning

Basit Öğe Kaydı
dc.contributor.authorVardar, Rukiye
dc.contributor.authorGunsar, Fulya
dc.contributor.authorErsoz, Galip
dc.contributor.authorAkarca, Ulus Salih
dc.contributor.authorKarasu, Zeki
dc.date.accessioned2019-10-27T21:17:55Z
dc.date.available2019-10-27T21:17:55Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: Consuming wild mushrooms is an ordinary habit in late summer and autumn in our region. Every year, several cases of hepatic toxicity secondary to mushroom poisoning are observed because of poor identification of the mushrooms. Unfortunately some of them are fatal. Prometheus system is a newly developed extracorporeal liver support device for fractionated plasma separation and adsorption (FPSA) that enables removal of albumin-bound and water-soluble toxins. Therefore, it may be a promising treatment option for patients with liver failure due to mushroom poisoning. Methodology: We studied 8 patients with mushroom poisoning. All patients underwent 1 to 4 consecutive FPSA (Prometheus)-system in addition to medical and supportive treatment such as fluid replacement, Penicillin G, N-acetylcysteine (NAC) and silymarin. A variety of clinical and biochemical parameters were assessed. Results: We had improvement of the biochemical parameters after first treatment with FPSA-system. Seven of 8 patients survived and were discharged to resume an independent life. One patient who had grade III encephalopathy when admitted to hospital died. No major adverse events were observed during the application of this therapy modality. Conclusions: FPSA-system may be a safe and effective treatment option for patient with mushroom poisoning. Early hospitalization is essential in order to be successful. Controlled studies are needed to evaluate the efficacy of this new treatment choice on survival of patients with acute liver failure (ALF) due to mushroom poisoning.en_US
dc.identifier.endpage577en_US
dc.identifier.issn0172-6390
dc.identifier.issue99-100en_US
dc.identifier.pmid20698230en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://hdl.handle.net/11454/43892
dc.identifier.volume57en_US
dc.identifier.wosWOS:000280557900036en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFractionated plasma separation and adsorptionen_US
dc.subjectArtificial liver supporten_US
dc.subjectMushroom poisoningen_US
dc.subjectAmanita phalloidesen_US
dc.titleEfficacy of Fractionated Plasma Separation and Adsorption System (Prometheus) for Treatment of Liver Failure Due to Mushroom Poisoningen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu