Genetic polymorphisms of interleukin 1 beta gene and sporadic pancreatic neuroendocrine tumors susceptibility

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dc.contributor.authorKarakaxas, Dimitrios
dc.contributor.authorSioziou, Anna
dc.contributor.authorAravantinos, Gerasimos
dc.contributor.authorCoker, Ahmet
dc.contributor.authorPapanikolaou, Ioannis S.
dc.contributor.authorLiakakos, Theodoros
dc.contributor.authorDervenis, Christos
dc.contributor.authorGazouli, Maria
dc.date.accessioned2019-10-27T23:09:27Z
dc.date.available2019-10-27T23:09:27Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractAIM: To evaluate the association between the inter-leukin 1 beta (IL-1 beta) polymorphisms and the pancreatic neuroendocrine tumor (pNET) development. METHODS: A case-control study was conducted analyzing IL-1 beta polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer (51 pNET cases, 85 pancreatic ductal adenocarcinoma cases, 19 intraductal papillary mucinous neoplasm and 98 healthy controls). RESULTS: The distribution of genotypes for the -511 C/T polymorphism in the pNET patient groups showed significant difference compared to the control group. It is known that the carriers of the IL-1 beta -511T allele have increased concentrations of IL-1 beta. The -511 CT and TT high-expression genotypes were over-represented in pNET patients. CONCLUSION: The findings of this study suggested a possible role of IL-1 beta -511 C/T genotypes in the pathogenesis of pNETs since the presence of the IL-1 beta -511 CT and TT genotypes and the T allele was associated with an increased risk of pNET only.en_US
dc.description.sponsorshipHellenic Society of Medical Oncology [5839/08-04-2015]en_US
dc.description.sponsorshipSupported by Hellenic Society of Medical Oncology, No. 5839/08-04-2015.en_US
dc.identifier.doi10.4251/wjgo.v8.i6.520en_US
dc.identifier.endpage525en_US
dc.identifier.issn1948-5204
dc.identifier.issue6en_US
dc.identifier.pmid27326321en_US
dc.identifier.startpage520en_US
dc.identifier.urihttps://doi.org/10.4251/wjgo.v8.i6.520
dc.identifier.urihttps://hdl.handle.net/11454/52651
dc.identifier.volume8en_US
dc.identifier.wosWOS:000408543000005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastrointestinal Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInterleukin 1 betaen_US
dc.subjectNeuroendocrine tumorsen_US
dc.subjectPancreasen_US
dc.titleGenetic polymorphisms of interleukin 1 beta gene and sporadic pancreatic neuroendocrine tumors susceptibilityen_US
dc.typeArticleen_US

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