Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

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dc.contributor.authorAkarcan, Sanem Eren
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorAksu, Guzide
dc.contributor.authorBozkaya, Halil
dc.contributor.authorAyik, Mehmet Fatih
dc.contributor.authorSahan, Yasemin Ozdemir
dc.contributor.authorKilinc, Mehmet Arda
dc.contributor.authorDokumcu, Zafer
dc.contributor.authorEraslan, Cenk
dc.contributor.authorDivarci, Emre
dc.contributor.authorAlper, Hudaver
dc.contributor.authorKutukculer, Necil
dc.date.accessioned2019-10-27T11:22:46Z
dc.date.available2019-10-27T11:22:46Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractChronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91 phox protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA genemutation affecting p22(phox) protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.en_US
dc.identifier.doi10.1155/2017/2676403en_US
dc.identifier.issn2090-6609
dc.identifier.issn2090-6617
dc.identifier.pmid28168067en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1155/2017/2676403
dc.identifier.urihttps://hdl.handle.net/11454/33079
dc.identifier.wosWOS:000394086700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofCase Reports in Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleNecrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypesen_US
dc.typeArticleen_US

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