The effects of branched-chain amino acids on the oxygen consumption in patients with metabolic stress [Metabolik stresli hastalarda dallanmis zincirli aminoasitlerin oksijen tuketimine etkisi]
Küçük Resim Yok
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In recent years, there has been a much controversy about the feasibility of amino acid solutions with a high content of branched-chain amino acids (BCAA: leucine, isoleucine, valine) in fields of hepatic failure, trauma, obtaining a better nitrogen balance, low morbidity and low mortality. The aim of this study was to establish the effects of BCAA infusions on the oxygen consumption (VO2) in patients with metabolic stress. We studied nine patients who were mechanically ventilated suffering from acute respiratory failure. Muscle relaxants, sedation and volum controlled mechanical ventilatory support were applied to all patients. Daily energy supply was obtained with standard enteral formulas 1 kcal/mL. In addition to daily energy requirement, 0,5 g/kg amino acid solution which contains % 45 BZAA was infused parenterally in 6 hours. Before (I) and after (II) 6 hours infusion VO2 were calculated with thermodilution technique via pulmonary arterial catheter. Wilcoxon was used for statistically comparisons. We conclude that, although the statistical difference was non-significant between two measurements there seems to be a relative increase of VO2 consumption with the use of BCAA and this may be important in the ICU for critically ill patients with poor oxygen supply.
Açıklama
Anahtar Kelimeler
Branched-chain amino acids, Metabolic stress, Oxygen consumption
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
27
Sayı
6
