The effect of day 2 FSH, LH, estradiol levels on ovarian response and pregnancy outcome in ART cycles induced by short protokol GnRH-a and gonadotropins [Kisa protokol GnRHa ve gonadotropinlerle ovulasyon induksiyonu yapilan yardimli ureme teknigi uygulamalarinda; siklus basi FSH, LH, Ostradiol duzeylerinin; ovarian cevap ve gebelik sonuclari uzerine etkileri]

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dc.contributor.authorTavmergen E.
dc.contributor.authorSendag F.
dc.contributor.authorTavmergen Goker E.N.
dc.contributor.authorBenli H.
dc.contributor.authorKocyigit F.
dc.date.accessioned2019-10-27T00:27:34Z
dc.date.available2019-10-27T00:27:34Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: This study was designed to evaluate the influence of serum E2, LH, FSH levels on the starting day of ovulation induction in ART cycles tooccyte maturity, fertilization rates, embryo quality and outcome of pregnancy. STUDY DESIGN: The blood levels of E2, LH, FSH were detected in patients on the 2nd day of the menstrual cycle when short protocol GnRH-a and FSH+HMG combinations were started for ovulation induction. The required gonadotropin dosage was compared to oocyte maturation, fertilization rates, embryo quality and pregnancy rates in different groups of E2, LH, FSH levels. RESULTS: 100 cases of IVF cycles without an andrologic factor and ICSI cycles were evaluated. The patients were evaluated for day 2 E2, LH, FSH levels divided into different groups as following; E2<50 pg/ml, 50 pg/ml ?E2 <75 pg/ml, E2 ?75 pg/ml; FSH < 5 miu/ml, 5 miu/ml ? FSH < 10 miu/ml, FSH ? 10 miu/ml; LH<5 miu/ml, LH ? miu/ml. Statistically significant differences were detected between day 2 E2 levels and the prognosis of pregnancy, cancellation rate of cycles. No statistically significant difference was detected with day 2 LH levels although negative correlation was detected between FSH levels and the dose of gonadotrophin hormone used, oocyte number, fertilization rates, embryo number and outcome of pregnancy. The cycle cancellation rate was higher in the group with high FSH levels. CONCLUSIONS: As a conclusion we have found that E2 levels <75 pg/ml and FSH levels <10 miu/ml on day 2, influences the outcome of ovulation induction, number of retrieved oocytes, fertilization rates, embryo number and pregnancy rates positively. In patients having higher hormone levels, the number of HMG and FSH ampules used for induction increases significantly which influences oocyte number, fertilization rates, embryo number and pregnancy rates negatively.en_US
dc.identifier.endpage43en_US
dc.identifier.issn1016-5126
dc.identifier.issn1016-5126en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://hdl.handle.net/11454/23546
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofJinekoloji ve Obstetrik Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectARTen_US
dc.subjectDay 2 FSHen_US
dc.subjectE2en_US
dc.subjectLHen_US
dc.subjectOvarian Responseen_US
dc.subjectPregnancy Outcomeen_US
dc.subjectShort Protokol GnRHaen_US
dc.titleThe effect of day 2 FSH, LH, estradiol levels on ovarian response and pregnancy outcome in ART cycles induced by short protokol GnRH-a and gonadotropins [Kisa protokol GnRHa ve gonadotropinlerle ovulasyon induksiyonu yapilan yardimli ureme teknigi uygulamalarinda; siklus basi FSH, LH, Ostradiol duzeylerinin; ovarian cevap ve gebelik sonuclari uzerine etkileri]en_US
dc.typeArticleen_US

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