The effect of day 2 FSH, LH, estradiol levels on ovarian response and pregnancy outcome in ART cycles induced by short protokol GnRH-a and gonadotropins [Kisa protokol GnRHa ve gonadotropinlerle ovulasyon induksiyonu yapilan yardimli ureme teknigi uygulamalarinda; siklus basi FSH, LH, Ostradiol duzeylerinin; ovarian cevap ve gebelik sonuclari uzerine etkileri]
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: This study was designed to evaluate the influence of serum E2, LH, FSH levels on the starting day of ovulation induction in ART cycles tooccyte maturity, fertilization rates, embryo quality and outcome of pregnancy. STUDY DESIGN: The blood levels of E2, LH, FSH were detected in patients on the 2nd day of the menstrual cycle when short protocol GnRH-a and FSH+HMG combinations were started for ovulation induction. The required gonadotropin dosage was compared to oocyte maturation, fertilization rates, embryo quality and pregnancy rates in different groups of E2, LH, FSH levels. RESULTS: 100 cases of IVF cycles without an andrologic factor and ICSI cycles were evaluated. The patients were evaluated for day 2 E2, LH, FSH levels divided into different groups as following; E2<50 pg/ml, 50 pg/ml ?E2 <75 pg/ml, E2 ?75 pg/ml; FSH < 5 miu/ml, 5 miu/ml ? FSH < 10 miu/ml, FSH ? 10 miu/ml; LH<5 miu/ml, LH ? miu/ml. Statistically significant differences were detected between day 2 E2 levels and the prognosis of pregnancy, cancellation rate of cycles. No statistically significant difference was detected with day 2 LH levels although negative correlation was detected between FSH levels and the dose of gonadotrophin hormone used, oocyte number, fertilization rates, embryo number and outcome of pregnancy. The cycle cancellation rate was higher in the group with high FSH levels. CONCLUSIONS: As a conclusion we have found that E2 levels <75 pg/ml and FSH levels <10 miu/ml on day 2, influences the outcome of ovulation induction, number of retrieved oocytes, fertilization rates, embryo number and pregnancy rates positively. In patients having higher hormone levels, the number of HMG and FSH ampules used for induction increases significantly which influences oocyte number, fertilization rates, embryo number and pregnancy rates negatively.
Açıklama
Anahtar Kelimeler
ART, Day 2 FSH, E2, LH, Ovarian Response, Pregnancy Outcome, Short Protokol GnRHa
Kaynak
Jinekoloji ve Obstetrik Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
13
Sayı
1
