The effect of statin therapy on ventricular late potentials in acute myocardial infarction

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dc.contributor.authorKayikcioglu, M
dc.contributor.authorCan, L
dc.contributor.authorEvrengul, H
dc.contributor.authorPayzin, S
dc.contributor.authorKultursay, H
dc.date.accessioned2019-10-27T19:00:02Z
dc.date.available2019-10-27T19:00:02Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description50th Annual Scientific Session of the American-College-of-Cardiology -- MAR 18-21, 2001 -- ORLANDO, FLen_US
dc.description.abstractAims: To determine whether early statin therapy in acute myocardial infarction has any effect on ventricular late potentials which are considered as a noninvasive tool for evaluation of arrhythmogenic substrate. Methods and results: Study population consisted of prospectively enrolled 72 patients presenting with acute myocardial infarction (<6 h). Thirty-four of the patients were randomized to pravastatin (40 mg/day) on admission irrespective of lipid levels. All patients received thrombolytic therapy. Signal-averaged ECG recordings were obtained serially prior to thrombolytic therapy, 48 h after and 10 days later. Late potentials were defined as positive if signal-averaged ECG met at least two of Gomes criteria: filtered total QRS duration > 114 ms, root mean square voltage of the last 40 ins of the QRS <20 mV, or the duration of the terminal low (<40 mV) amplitude signals >38 ms. Changes observed in signal-averaged ECG recordings after thrombolysis were evaluated statistically with regard to statin usage. There were no significant differences between the clinical characteristics of the two randomized groups. There was a significant decrease in the rates of late potentials between the first and third signal-averaged ECG recordings after thrombolytic therapy in pravastatin group. Pravastatin group also had lower incidence of ventricular arrhythmias compared with control group (26 vs. 63%, P=0.021). The in-hospital cardiovascular event rates were also lower in statin group. Conclusion: Early use of pravastatin reduces the incidence of late potentials following thrombolytic therapy in acute myocardial infarction. Statin therapy also seems to be reducing the incidence of in-hospital ventricular arrhythmias. These beneficial effects of statins might be explained through prevention of new myocardial ischemic episodes due to early plaque stabilization or regulation of endothelial and platelet functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipAmer Coll Cardiolen_US
dc.identifier.doi10.1016/S0167-5273(02)00516-8en_US
dc.identifier.endpage72en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue1en_US
dc.identifier.pmid12821221en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-5273(02)00516-8
dc.identifier.urihttps://hdl.handle.net/11454/37722
dc.identifier.volume90en_US
dc.identifier.wosWOS:000184608200010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpravastatinen_US
dc.subjectthrombolytic therapyen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectsignal averaged electrocardiographyen_US
dc.subjectlate potentialsen_US
dc.subjectventricular arrhythmiasen_US
dc.titleThe effect of statin therapy on ventricular late potentials in acute myocardial infarctionen_US
dc.typeArticleen_US

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