Recent progresses in natural based therapeutic materials for Alzheimer's disease

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dc.authoridEftekhari, Aziz/0000-0003-0274-4479
dc.authoridBeylerli, Ozal/0000-0002-6149-5460
dc.authoridValioglu, Ferzane/0000-0002-9388-3214
dc.authoridZivari-Ghader, Tayebeh/0000-0003-1571-069X
dc.contributor.authorZivari-Ghader, Tayebeh
dc.contributor.authorValioglu, Ferzane
dc.contributor.authorEftekhari, Aziz
dc.contributor.authorAliyeva, Immi
dc.contributor.authorBeylerli, Ozal
dc.contributor.authorDavran, Soodabeh
dc.contributor.authorCho, William C.
dc.date.accessioned2024-08-31T07:49:45Z
dc.date.available2024-08-31T07:49:45Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAlzheimer's disease is a neurological disorder that causes increased memory loss, mood swings, behavioral disorders, and disruptions in daily activities. Polymer scaffolds for the brain have been grown under laboratory, physiological, and pathological circumstances because of the limitations of conventional treatments for patients with central nervous system diseases. The blood -brain barrier prevents medications from entering the brain, challenging AD treatment. Numerous biomaterials such as biomolecules, polymers, inorganic metals, and metal oxide nanoparticles have been used to transport therapeutic medicines into the nervous system. Incorporating biocompatible materials that support neurogenesis through a combination of topographical, pharmacological, and mechanical stimuli has also shown promise for the transfer of cells to replenish dopaminergic neurons. Components made of naturally occurring biodegradable polymers are appropriate for the regeneration of nerve tissue. The ability of natural -based materials (biomaterials) has been shown to promote endogenous cell development after implantation. Also, strategic functionalization of polymeric nanocarriers could be employed for treating AD. In particular, nanoparticles could resolve A beta aggregation and thus help cure Alzheimer's disease. Drug moieties can be effectively directed to the brain by utilizing nano -based systems and diverse colloidal carriers, including hydrogels and biodegradable scaffolds. Notably, early investigations employing neural stem cells have yielded promising results, further emphasizing the potential advancements in this field. Few studies have fully leveraged the combination of cells with cuttingedge biomaterials. This study provides a comprehensive overview of prior research, highlighting the pivotal role of biomaterials as sophisticated drug carriers. It delves into various intelligent drug delivery systems, encompassing pH and thermo-triggered mechanisms, polymeric and lipid carriers, inorganic nanoparticles, and other vectors. The discussion synthesizes existing knowledge and underscores the transformative impact of these biomaterials in devising innovative strategies, augmenting current therapeutic methodologies, and shaping new paradigms in the realm of Alzheimer's disease treatment.en_US
dc.description.sponsorshipBashkir State Medical University Strategic Academic Leadership Program [PRIORITY-2030]; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute of Tabriz University of Medical Sciences, Tabriz, Iran [73829]en_US
dc.description.sponsorshipThis work was supported by Bashkir State Medical University Strategic Academic Leadership Program (PRIORITY-2030) . This work also was supported by the Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute of Tabriz University of Medical Sciences, Tabriz, Iran (Grant no: 73829) .en_US
dc.identifier.doi10.1016/j.heliyon.2024.e26351
dc.identifier.issn2405-8440
dc.identifier.issue4en_US
dc.identifier.pmid38434059en_US
dc.identifier.scopus2-s2.0-85185810539en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e26351
dc.identifier.urihttps://hdl.handle.net/11454/104989
dc.identifier.volume10en_US
dc.identifier.wosWOS:001201916700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofHeliyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNatural Biomaterialsen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectScaffolden_US
dc.subjectLiposomeen_US
dc.subjectHydrogelen_US
dc.titleRecent progresses in natural based therapeutic materials for Alzheimer's diseaseen_US
dc.typeReview Articleen_US

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