Radiolabeling of Morphine with I-131 and Its Biodistribution in Rats

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dc.contributor.authorEnginar, Hueseyin
dc.contributor.authorUnak, Perihan
dc.contributor.authorYurt-Lambrecht, Fatma
dc.contributor.authorBiber-Mueftueler, Fazilet Z.
dc.contributor.authorSeyitoglu, Beyza
dc.contributor.authorYurt, Ayfer
dc.contributor.authorYolcular, Seniha
dc.contributor.authorMedine, Ilker
dc.contributor.authorBulduk, Ibrahim
dc.date.accessioned2019-10-27T21:15:43Z
dc.date.available2019-10-27T21:15:43Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study was conducted to determine the possible radiopharmaceutical potential of morphin labeled with I-131. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.), purified by high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified compound was labeled with I-131. Male Albino Wistar rats (18) were used for receptor blockage and unblockage biodistribution studies. Tissue distribution studies showed that radiolabeled morphine had higher uptake in lung, liver, small intestines, large intestines, and stomach than the other tissues. The highest uptake of radiolabeled compounds in rats' brain was found to be in the midbrain and hypothalamus. After receptor blockage with morphine, uptake of I-131-morphine decreased in the lungs, liver, kidney, testis, prostate, spinal cord, cerebellum, hippocampus, striatum, and temporal cortex with respect to receptor unblockage studies of rats. This study concludes that the labeling yield of I-131-morphine was high, high amount of I-131-morphine was found in the hypothalamus, and I-131-morphine has enough stability for diagnostic scanning.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2004-104T187]; T.R. Prime Ministry State Planning Organization (DPT)Turkiye Cumhuriyeti Kalkinma Bakanligi [2006 DPT 06]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK, Project Number 2004-104T187) and T.R. Prime Ministry State Planning Organization (DPT, Project Number 2006 DPT 06).en_US
dc.identifier.doi10.1089/cbr.2010.0774en_US
dc.identifier.endpage416en_US
dc.identifier.issn1084-9785
dc.identifier.issue4en_US
dc.identifier.pmid20707720en_US
dc.identifier.startpage409en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2010.0774
dc.identifier.urihttps://hdl.handle.net/11454/43570
dc.identifier.volume25en_US
dc.identifier.wosWOS:000281255100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiodistributionen_US
dc.subjectI-131en_US
dc.subjectmorphineen_US
dc.subjectradiolabelingen_US
dc.titleRadiolabeling of Morphine with I-131 and Its Biodistribution in Ratsen_US
dc.typeArticleen_US

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