From Invisible Structures of SWCNTs toward Fluorescent and Targeting Architectures for Cell Imaging

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dc.contributor.authorAg, Didem
dc.contributor.authorSeleci, Muharrem
dc.contributor.authorBongartz, Rebecca
dc.contributor.authorCan, Mustafa
dc.contributor.authorYurteri, Seda
dc.contributor.authorCianga, Ioan
dc.contributor.authorStahl, Frank
dc.contributor.authorTimur, Suna
dc.contributor.authorScheper, Thomas
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T22:07:47Z
dc.date.available2019-10-27T22:07:47Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractSingle-walled carbon nanotubes (SWNTs) are unique nanostructures used as cargo systems for variety of diagnostic and therapeutic agents. For taking advantage of these structures in biological processes, they should be visible. Therefore, fluorescence labeling of SWCNTs with various probes is a significant issue. Herein, we demonstrate a simple approach for cell specific imaging and diagnosis by combining SWCNTs with a copolymer poly(para-epsilon-caprolactone) (PCL) side chains (PPP-g-PSt-PCL). In this approach PPP-g-PSt-PCL is noncovalently attached on carboxyl functional SWCNTs. The obtained fluorescent probe is bound to folic acid (FA) for targeted imaging of folate receptor (FR) positive HeLa cells. In vitro studies demonstrate that this conjugate can specifically bind to HeLa cells and indicate great potential for targeting and imaging studies.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T573]; EBILTEMEge University [2010 BIL 004]en_US
dc.description.sponsorshipThis work was supported by TUBITAK (Project No.109T573) and EBILTEM (Project No. 2010 BIL 004).en_US
dc.identifier.doi10.1021/bm400862men_US
dc.identifier.endpage3541en_US
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.issue10en_US
dc.identifier.pmid23987303en_US
dc.identifier.startpage3532en_US
dc.identifier.urihttps://doi.org/10.1021/bm400862m
dc.identifier.urihttps://hdl.handle.net/11454/49076
dc.identifier.volume14en_US
dc.identifier.wosWOS:000326122800022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofBiomacromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFrom Invisible Structures of SWCNTs toward Fluorescent and Targeting Architectures for Cell Imagingen_US
dc.typeArticleen_US

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