The use of N-terminal (1-76) pro-brain natriuretic peptide in the aetiology of severe respiratory distress in the paediatric emergency department

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dc.authoriddogan, eser/0000-0002-0340-7741
dc.authorscopusid57203459114
dc.authorscopusid57194763753
dc.authorscopusid41662339000
dc.authorscopusid57226082352
dc.authorscopusid35312096900
dc.contributor.authorDogan, Eser
dc.contributor.authorTuran, Caner
dc.contributor.authorYurtseven, Ali
dc.contributor.authorTuran, Benay
dc.contributor.authorSaz, Eylem Ulas
dc.date.accessioned2023-01-12T19:58:32Z
dc.date.available2023-01-12T19:58:32Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractIntroduction: Acute respiratory distress is one of the most common reasons for paediatric emergency visits. Paediatric patients require rapid diagnosis and treatment. Our aim in this study was to use N-terminal (1-76) pro-brain natriuretic peptide to differentiate respiratory distress of cardiac and pulmonary origin in children. Our aim was to investigate the role of N-terminal (1-76) pro-brain natriuretic peptide in the detection of patients with new-onset heart failure in the absence of an underlying congenital heart anomaly. Methods: All children aged 0-18 years who presented to the paediatric emergency department due to severe respiratory distress were included in the study prospectively. The patients' demographic characteristics, presenting complaints, clinical findings, and N-terminal (1-76) pro-brain natriuretic peptide concentrations, were investigated. In patients with severe Pediatric Respiratory Severity Score, congestive heart failure score was calculated using the modified Ross Score. Results: This study included 47 children between the ages of 1 month and 14 years. The median N-terminal (1-76) pro-brain natriuretic peptide concentration was 5717 (IQR:16158) pg/mL in the 25 patients with severe respiratory distress due to heart failure and in the 22 patients with severe respiratory distress due to lung pathology was 437 (IQR:874) pg/mL (p < 0.001). In the 25 patients with severe respiratory distress due to heart failure, 8281 (IQR:8372) pg/mL in the 16 patients with underlying congenital heart anomalies, and 1983 (IQR:2150) pg/mL in the 9 patients without a congenital heart anomaly (p < 0.001). The 45 patients in the control group had a median N-terminal (1-76) pro-brain natriuretic peptide concentration of 47.2 (IQR:56.2) pg/mL. Conclusion: Using scoring systems in combination with N-terminal (1-76) pro-brain natriuretic peptide cut-off values can help direct and manage treatment.en_US
dc.identifier.doi10.1017/S104795112100490X
dc.identifier.endpage1767en_US
dc.identifier.issn1047-9511
dc.identifier.issn1467-1107
dc.identifier.issue11en_US
dc.identifier.pmid34915965en_US
dc.identifier.scopus2-s2.0-85121389407en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1761en_US
dc.identifier.urihttps://doi.org/10.1017/S104795112100490X
dc.identifier.urihttps://hdl.handle.net/11454/76943
dc.identifier.volume32en_US
dc.identifier.wosWOS:000731190100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology in The Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-terminal brain natriuretic peptideen_US
dc.subjectrespiratory distressen_US
dc.subjectheart failureen_US
dc.subjectemergency departmenten_US
dc.subjectCongenital Heart-Diseaseen_US
dc.subjectChildrenen_US
dc.subjectFailureen_US
dc.subjectBnpen_US
dc.titleThe use of N-terminal (1-76) pro-brain natriuretic peptide in the aetiology of severe respiratory distress in the paediatric emergency departmenten_US
dc.typeArticleen_US

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