Prolactin effect on blood glucose and insülin in breastfeeding women

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dc.contributor.authorOzisik H.
dc.contributor.authorSuner A.
dc.contributor.authorCetinkalp S.
dc.date.accessioned2019-10-27T08:00:56Z
dc.date.available2019-10-27T08:00:56Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Prolactin plays a significant role in lactation and prolactin levels are increasing physiologically in pregnancy and breastfeeding period. There might be different mechanisms during breastfeeding between prolactin and insülin levels. In order to highlighten this mechanisms we compared the plasma levels of glucose, insülin, prolactin, C-peptid in basal situations and after taking 75 gr carbonhydrate, 20 gr protein, 23 gr fat in breastfeeding and in non lactating women. Material and methods: Participiants and measurements: The study population included 12 breastfeeding women and 11 healthy non lactating women as a control group. We collected information on age, history of gestational diabetes mellitus, family history of diabetes mellitus, natality, the symptoms of hypoglycemia. Weight, height and waist circumference were measured and body mass index (BMI) was calculated as weight (kg)/height (m 2 ). Results: Prolactin was inversely correlated with HbA1c and 2. hour C peptide (p=0.005, r=-0.564; p=0.008, r=-0.539). Prolactin was not significantly correlated with HOMA-IR, HOMA-IS, AUC-I or AUC-G. Prolactin levels were higher in breastfeeding women (median:34.98 µg/L) than in non lactating women (median:12.21 µg/L, p<0.001). There was a significant association between age and fasting glucose (p=0.018, r=-0.665), 2. hour glucose (p=0.049, r=0.578) in breastfeeding women. Discussion: In our study, we displayed prolactin was inversely correlated with HbA1c and 2. hour C peptide. Some studies in the past demonstrated that higher prolactin levels had importantly lower prevelance of type 2 diabetes. Our findings supported this situation. © 2019 Diabetes Indiaen_US
dc.identifier.doi10.1016/j.dsx.2019.03.045en_US
dc.identifier.endpage1767en_US
dc.identifier.issn1871-4021
dc.identifier.issue3en_US
dc.identifier.pmid31235091en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1765en_US
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2019.03.045
dc.identifier.urihttps://hdl.handle.net/11454/24879
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofDiabetes and Metabolic Syndrome: Clinical Research and Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleProlactin effect on blood glucose and insülin in breastfeeding womenen_US
dc.typeArticleen_US

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