The risk factors for a poor hematopoietic stem cell mobilization in lymphoma patients
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Tarih
2017
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Yetersiz mobilizasyon otolog kök hücre naklinde halen önemli bir sorun olmaya devam etmektedir. Lenfoma hastalarında yetersiz mobilizasyon daha sık izlenmekle birlikte nedenleri konusunda yeterli bilgi bulunmamaktadır. Bu çalışmamızda, 57 lenfoma hastasında yetersiz maobilzasyona neden olabilecek risk faktörlerini belirlemeye çalıştık. Gereç ve Yöntem: 1998-2011 tarihleri arasında mobilizasyon uygulanan 57 (40 non-Hodgkin lenfoma ve 17 Hodgkin lenfoma) lenfoma hastasını geriye dönük olarak taradık. Hasta bilgilerine hematoloji kliniği arşivinden ulaşıldı. Bulgular: On üç hastada (%22.8) yetersiz mobilizasyon saptandı. Kemik iliği infiltrasyonu (odds ratio [OR] =15.52, p=0.002) ve 10'dan fazla kür kemoterapi almış olmak (OR=6.25, p=0.04 ) risk faktörü olarak belirlendi. Sonuç: Yetersiz mobilizasyona neden olabilecek risk faktörlerinin bilinmesi ve bu risk faktörlerine sahip olan hasta grubunun önceden belirlenmesi kaynakların daha verimli kullanılması açısından önem taşımaktadır.
Aim: Poor mobilization is an important problem in autologous stem cell transplantation. The ratio of poor mobilization is higher in lymphoma patients. There is limited data about poor mobilization in lymphoma patients. We aimed to identify the possible risk factors for poor mobilization using data from 57 lymphoma patients. Materials and Methods: We retrospectively reviewed the data of 57 lymphoma patients (40 with non-Hodgkin lymphoma and 17 with Hodgkin lymphoma) who have been mobilized during 1998 - 2011. Patient data were recruited from the archives of the hematology clinic. Results: We documented poor mobilization in 13 (22.8%) patients. Bone marrow involvement (odds ratio [OR] =15.52, p=0.002) and being treated with more than ten cycles of chemotherapies (OR=6.25, p=0.04) were found to be possible risk factors. Conclusion: Leukapheresis staff should be aware of the increased risk of poor mobilization in these cases and remobilization strategies should be considered from the beginning in these patients with risk factors for more effective resource utilization.
Aim: Poor mobilization is an important problem in autologous stem cell transplantation. The ratio of poor mobilization is higher in lymphoma patients. There is limited data about poor mobilization in lymphoma patients. We aimed to identify the possible risk factors for poor mobilization using data from 57 lymphoma patients. Materials and Methods: We retrospectively reviewed the data of 57 lymphoma patients (40 with non-Hodgkin lymphoma and 17 with Hodgkin lymphoma) who have been mobilized during 1998 - 2011. Patient data were recruited from the archives of the hematology clinic. Results: We documented poor mobilization in 13 (22.8%) patients. Bone marrow involvement (odds ratio [OR] =15.52, p=0.002) and being treated with more than ten cycles of chemotherapies (OR=6.25, p=0.04) were found to be possible risk factors. Conclusion: Leukapheresis staff should be aware of the increased risk of poor mobilization in these cases and remobilization strategies should be considered from the beginning in these patients with risk factors for more effective resource utilization.
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Cerrahi
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Cilt
56
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1
