The effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat model

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dc.authorscopusid55147311200
dc.authorscopusid7003977586
dc.authorscopusid55574410100
dc.authorscopusid8398093000
dc.authorscopusid13409253000
dc.authorscopusid7005809651
dc.authorscopusid7102876720
dc.contributor.authorDuman E.
dc.contributor.authorCeylan K.C.
dc.contributor.authorAkpınar D.
dc.contributor.authorYücel N.
dc.contributor.authorÜnsal Ş.
dc.contributor.authorDuman S.
dc.contributor.authorKaya Ş.Ö.
dc.date.accessioned2023-01-12T20:23:12Z
dc.date.available2023-01-12T20:23:12Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractOBJECTIVES: The effect of non-steroidal anti-inflammatory drugs (NSAID), mostly used for postoperative analgesic purposes for wound healing, is still a matter of debate. Our goal was to evaluate the effects of the most widely used NSAID and corticosteroids after surgical operations on tracheal wound healing in an experimental rat model. METHODS: Thirty-nine male Wistar albino rats were included in this study. Tracheotomy was performed in 32 rats; then they were divided into 3 groups. After the first day, the animals in group 1 were treated with an NSAID (diclofenac 10 mg/kg/day) (NSAID, n = 12) for 7 days; the animals in group 2 were treated with a corticosteroid (dexamethasone, 2 × 0.1 mg/kg/day) (steroid, n = 10) for 7 days; the animals in group 3 (control, n = 10) were not given any medications. For a fourth group (histological control, n = 7), in order to evaluate normal morphological and histological characteristics, neither surgery nor medication was used. Five rats were eliminated from the study (2 rats in the NSAID group died and 3 rats in the steroid group developed local wound infections). The drop-out rate was 12.8%. Histological characteristics, inflammation, fibrosis, necrosis, neochondrogenesis, neovascularization and epithelization were evaluated in 34 rats. Nonparametric tests were used for statistical analysis. RESULTS: Inflammation, vascularization and number of fibroblasts and chondrocytes were significantly higher in the control group than in the histological control group. There was some reduction in all parameters except vascularization in the NSAID group (P > 0.05). When the steroid group was compared to the NSAID group, inflammation (P < 0.05), vascularization and number of chondrocytes (P > 0.05) were more suppressed in the steroid group. The number of fibroblasts increased in the steroid group (P > 0.05). CONCLUSIONS: Steroids and NSAID may have negative effects on tracheal wound healing, probably by suppressing inflammation and fibroblast proliferation. NSAID was mostly used postoperatively for analgesic purposes and should be avoided. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.en_US
dc.identifier.doi10.1093/ICVTS/IVZ309
dc.identifier.endpage651en_US
dc.identifier.issn1569-9293
dc.identifier.issue4en_US
dc.identifier.pmid31953943en_US
dc.identifier.scopus2-s2.0-85082561167en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage646en_US
dc.identifier.urihttps://doi.org/10.1093/ICVTS/IVZ309
dc.identifier.urihttps://hdl.handle.net/11454/79659
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofInteractive Cardiovascular and Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectSteroidsen_US
dc.subjectWound healingen_US
dc.subjectcorticosteroid derivativeen_US
dc.subjectdexamethasoneen_US
dc.subjectdiclofenacen_US
dc.subjectnonsteroid antiinflammatory agenten_US
dc.subjectdexamethasoneen_US
dc.subjectdiclofenacen_US
dc.subjectglucocorticoiden_US
dc.subjectnonsteroid antiinflammatory agenten_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiinflammatory activityen_US
dc.subjectArticleen_US
dc.subjectcell proliferationen_US
dc.subjectchondrocyteen_US
dc.subjectchondrogenesisen_US
dc.subjectcontrolled studyen_US
dc.subjectdeathen_US
dc.subjectdrug effecten_US
dc.subjectepithelizationen_US
dc.subjectexperimental raten_US
dc.subjectfibroblasten_US
dc.subjectfibrosisen_US
dc.subjecthistopathologyen_US
dc.subjectinflammationen_US
dc.subjectmaleen_US
dc.subjectnecrosisen_US
dc.subjectneovascularization (pathology)en_US
dc.subjectnonhumanen_US
dc.subjectnonparametric testen_US
dc.subjectpatient dropouten_US
dc.subjectraten_US
dc.subjectrat modelen_US
dc.subjectsurgical infectionen_US
dc.subjecttrachea injuryen_US
dc.subjecttracheotomyen_US
dc.subjectvascularizationen_US
dc.subjectWistar raten_US
dc.subjectwound healingen_US
dc.subjectanimalen_US
dc.subjectdrug effecten_US
dc.subjectpathologyen_US
dc.subjecttracheaen_US
dc.subjectwound healingen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Inflammatory Agents, Non-Steroidalen_US
dc.subjectDexamethasoneen_US
dc.subjectDiclofenacen_US
dc.subjectGlucocorticoidsen_US
dc.subjectInflammationen_US
dc.subjectMaleen_US
dc.subjectModels, Animalen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectTracheaen_US
dc.subjectTracheotomyen_US
dc.subjectWound Healingen_US
dc.titleThe effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat modelen_US
dc.typeArticleen_US

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