Smart Multiplex Point-of-Care Platform for Simultaneous Drug Monitoring

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dc.authoridDe Oliveira Filho, Jose Ilton/0000-0002-8367-4398
dc.authoridBeduk, Duygu/0000-0002-5394-4967
dc.authoridSalama, Khaled Nabil/0000-0001-7742-1282
dc.authorscopusid57224474138
dc.authorscopusid57205630119
dc.authorscopusid57200415199
dc.authorscopusid56189842000
dc.authorscopusid25625877200
dc.authorscopusid57564391200
dc.authorscopusid57203414946
dc.authorwosidDe Oliveira Filho, Jose Ilton/R-7074-2016
dc.authorwosidSalama, Khaled Nabil/H-6533-2011
dc.contributor.authorBedük, Duygu
dc.contributor.authorBeduk, Tutku
dc.contributor.authorde Oliveira Filho, Josei Ilton
dc.contributor.authorLahcen, Abdellatif Ait
dc.contributor.authorAldemir, Ebru
dc.contributor.authorGüler Çelik, Emine
dc.contributor.authorSalama, Khaled Nabil
dc.date.accessioned2024-08-25T18:48:06Z
dc.date.available2024-08-25T18:48:06Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractRecently, illicit drug use has become more widespreadand is linkedto problems with crime and public health. These drugs disrupt consciousness,affecting perceptions and feelings. Combining stimulants and depressantsto suppress the effect of drugs has become the most common reasonfor drug overdose deaths. On-site platforms for illicit-drug detectionhave gained an important role in dealing, without any excess equipment,long process, and training, with drug abuse and drug trafficking.Consequently, the development of rapid, sensitive, noninvasive, andreliable multiplex drug-detecting platforms has become a major necessity.In this study, a multiplex laser-scribed graphene (LSG) sensing platformwith one counter, one reference, and three working electrodes wasdeveloped for rapid and sensitive electrochemical detection of amphetamine(AMP), cocaine (COC), and benzodiazepine (BZD) simultaneously in salivasamples. The multidetection sensing system was combined with a custom-madepotentiostat to achieve a complete point-of-care (POC) platform. Smartphoneintegration was achieved by a customized application to operate, display,and send data. To the best of our knowledge, this is the first multiplexLSG-based electrochemical platform designed for illicit-drug detectionwith a custom-made potentiostat device to build a complete POC platform.Each working electrode was optimized with standard solutions of AMP,COC, and BZD in the concentration range of 1.0 pg/mL-500 ng/mL.The detection limit of each illicit drug was calculated as 4.3 ng/mLfor AMP, 9.7 ng/mL for BZD, and 9.0 ng/mL for COC. Healthy and MET(methamphetamine) patient saliva samples were used for the clinicalstudy. The multiplex LSG sensor was able to detect target analytesin real saliva samples successfully. This multiplex detection deviceserves the role of a practical and affordable alternative to conventionaldrug-detection methods by combining multiple drug detections in oneportable platform.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of Development [2016K121190]; Ege University; King Abdullah University of Science and Technology (KAUST) Saudi Arabia; KAUST Smart-Health Initiative; Scientific and Technological Research Council of Turkey (TUBITAK) [221Z083]en_US
dc.description.sponsorshipThe authors would like to thank the Ege University Central Research Testing and Analysis Laboratory Application and Research Center (EGE-MATAL) for providing the equipment and the Republic of Turkey, Ministry of Development (Project Grant No: 2016K121190); Ege University; and King Abdullah University of Science and Technology (KAUST) Saudi Arabia and KAUST Smart-Health Initiative for the financial support. This work was also partly supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project Grant No: 221Z083).en_US
dc.identifier.doi10.1021/acsami.3c06461
dc.identifier.endpage37258en_US
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.issue31en_US
dc.identifier.pmid37499237en_US
dc.identifier.scopus2-s2.0-85167480162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage37247en_US
dc.identifier.urihttps://doi.org/10.1021/acsami.3c06461
dc.identifier.urihttps://hdl.handle.net/11454/102151
dc.identifier.volume15en_US
dc.identifier.wosWOS:001037684300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Applied Materials & Interfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectmultiplex sensingen_US
dc.subjectlaser-scribed grapheneen_US
dc.subjectillicit drugsen_US
dc.subjectcocaineen_US
dc.subjectamphetamineen_US
dc.subjectbenzodiazepineen_US
dc.subjectpoint-of-care testing (POC)en_US
dc.subjectIllicit Drugsen_US
dc.subjectStimulantsen_US
dc.subjectCovid-19en_US
dc.titleSmart Multiplex Point-of-Care Platform for Simultaneous Drug Monitoringen_US
dc.typeArticleen_US

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