Prognostic significance of early complete response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy: Multicentric study of Turkish Society for Radiation Oncology Group (TROD)

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dc.contributor.authorGörken, İlknur
dc.contributor.authorYalman, Deniz
dc.contributor.authorSert, Fatma
dc.contributor.authorSağlam, Esra Kaytan
dc.contributor.authorÖzkök, Serdar
dc.contributor.authorKılıç, Diclehan
dc.contributor.authorAlıcıkuş, Zümre Arıcan
dc.date.accessioned2023-01-12T20:32:36Z
dc.date.available2023-01-12T20:32:36Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground/Aims: To assess the effect of various parameters on the oncologic outcomes, including the time interval between therapy and surgery (S) in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy (CRT).Materials and Methods: The data of 914 LARC patients who received preoperative CRT between 1994 and 2015 were collected retrospectively. Patients received 45-50.4 Gy RT with 5FU based chemotherapy (CT). They all underwent radical resection followed by maintenance CT. Clinical and pathologic variables were compared between the pCR and no-pCR groups. Survival was estimated by the Kaplan-Meier method and Cox proportional hazard model was used in multivariate analysis.Results: After median follow-up of 60.5 (range=12-297.6) months, median overall survival (OS) was 58.75 months and disease-free survival (DFS) 53.32 months. pCR was observed in 18.9% of all cases. pCR, lymphovascular invasion and metastatic lymph node ratio (mLNR) were significantly associated with OS and DFS on multivariate analysis. The 5-year OS and DFS rates were better in pCR group (95.3% vs 80.7% for OS, p<0.0001 and 87.4% vs 71% for DFS, p<0.0001). pCR patients with 4-8 weeks interval had lower rates of distant metastasis (9% vs 20%, p=0.01) and any recurrences (13.6% vs 29.6%, p=0.001) than the remaining. Both OS and DFS were better in favor of pCR achieved at 4-8 week interval time (p<0.0001 for each).Conclusion: pCR after preoperative CRT in LARC correlated with better oncologic outcome. The best OS and DFS durations were achieved in patients who experienced pCR after 4-8-weeks interval before surgery.en_US
dc.identifier.doi10.5152/tjg.2020.19225
dc.identifier.endpage377en_US
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.startpage368en_US
dc.identifier.trdizinid424503en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2020.19225
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/424503
dc.identifier.urihttps://hdl.handle.net/11454/81173
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePrognostic significance of early complete response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy: Multicentric study of Turkish Society for Radiation Oncology Group (TROD)en_US
dc.typeArticleen_US

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