Malign plevral efüzyonlarda intraplevral bleomisin tedavisi
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ocak 1997-Mart 1999 tarihleri arasında Ege Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı'na başvuran, histolojik olarak malign plörezi tanısı almış ve beklenen yaşam süresi 1 aydan fazla olan 35 hasta çalışmaya alınmıştır. Hastalara intraplevral olarak 1U/kg bleomisin verilerek bu uygulamanın etkinliği ve buna etki eden faktörler araştırılmıştır. Hastaların 17'si kadın 18'i erkek olup, yaş ortalaması 57.6±15.9 olarak hesaplanmıştır. Yirmi beş hastada toraks dreni, on hastada ise torasentez ile sıvı tamamen boşaltılıp bleomisin uygulanmıştır. Yedi olguda, ek olarak, devam etmekte olan kemoterapi programı sürdürülmüştür. Birinci ayda tam yanıt veren 9 kişi, kısmi yanıt veren 15 kişi olmak üzere toplam 24 kişide (%75) yanıt sağlanmıştır. Plöredez sonrası kemoterapi alanlarla, sadece plöredez uygulananlar arasında yanıt açısından istatistiksel farklılık saptanmamıştır (%85.7, %72, p >0.05). En sık saptanan yan etkinin ise tolere edilebilir düzeyde göğüs ağrısı olduğu gözlenmiştir.
Treatment of Malignant Pleural Effusions with Intrapleural Bleomycin Between January 1997 and March 1999, intrapleural bleomycin (1U/kg) was administered to 35 patients with malignant pleural effusions. Patients who were not appropriate to receive systemic chemotherapy or did not benefit from the treatment and whose life expectancy was a month or more were eligible for this study. Seventeen patients were female and 18 were male. Mean age was 57.6±15.9. Tube thoracostomy was performed to 25 patients, and the rest 10 were treated with repeated thoracocentesis. Seven patients continued receiving systemic chemotherapy due to primary tumor response. Response was evaluated one month later. Total response rate was 75% (complete response 37.5%). No statistical difference was observed between the patients who received systemic chemotherapy after pleurodesis and the ones who did not receive any chemotherapy (85.7%, 72%, p >0.05). the most common side effects were tolerable pleuritic pain and fever.
Treatment of Malignant Pleural Effusions with Intrapleural Bleomycin Between January 1997 and March 1999, intrapleural bleomycin (1U/kg) was administered to 35 patients with malignant pleural effusions. Patients who were not appropriate to receive systemic chemotherapy or did not benefit from the treatment and whose life expectancy was a month or more were eligible for this study. Seventeen patients were female and 18 were male. Mean age was 57.6±15.9. Tube thoracostomy was performed to 25 patients, and the rest 10 were treated with repeated thoracocentesis. Seven patients continued receiving systemic chemotherapy due to primary tumor response. Response was evaluated one month later. Total response rate was 75% (complete response 37.5%). No statistical difference was observed between the patients who received systemic chemotherapy after pleurodesis and the ones who did not receive any chemotherapy (85.7%, 72%, p >0.05). the most common side effects were tolerable pleuritic pain and fever.
Açıklama
Anahtar Kelimeler
Kulak, Burun, Boğaz
Kaynak
Toraks Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
1
Sayı
3
