Effect of pulsatile flow during cardiopulmonary bypass on thyroid hormone metabolism

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dc.contributor.authorBuket S.
dc.contributor.authorAlayunt A.
dc.contributor.authorOzbaran M.
dc.contributor.authorHamulu A.
dc.contributor.authorDiscigil B.
dc.contributor.authorCetindag B.
dc.contributor.authorOzkilic H.
dc.contributor.authorBalkan Z.
dc.contributor.authorBilkay O.
dc.contributor.authorDurmaz I.
dc.date.accessioned2019-10-27T00:33:31Z
dc.date.available2019-10-27T00:33:31Z
dc.date.issued1994
dc.departmentEge Üniversitesien_US
dc.description.abstractChanges in thyroid hormone levels during and after cardiopulmonary bypass (CPB) are well documented. However, little is known about the effects of pulsatile flow during CPB on thyroid hormone metabolism. To examine the effect of flow pattern, a prospective study was carried out using 30 patients undergoing coronary artery bypass grafting. Fifteen patients had pulsatile flow during CPB and 15, nonpulsatile flow. Serum samples were obtained preoperatively, during bypass, and at 2 and 24 hours postoperatively. Thyroid-stimulating hormone, thyroxine (T4), triiodothyronine (T3), free T4, and free T3 levels were measured by radioimmunoassay. All measured hormone levels except free T4 and thyroid-stimulating hormone decreased after the initiation of CPB. There were no differences in preoperative values between the two groups. However, levels of T3 and free T3 during and after CPB showed a significant difference between the two groups, with a smaller decrease in patients in whom pulsatile flow was used during bypass (p < 0.05). Thyroxine, and thyroid-stimulating hormone free T4 values showed no difference between the two groups at any sampling time. These data provide support for the use of pulsatile flow during CPB to establish a more physiologic state and maintain better thyroid hormone metabolism. © 1994.en_US
dc.identifier.endpage96en_US
dc.identifier.issn0003-4975
dc.identifier.issue1en_US
dc.identifier.pmid8037567en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://hdl.handle.net/11454/24075
dc.identifier.volume58en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofThe Annals of Thoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of pulsatile flow during cardiopulmonary bypass on thyroid hormone metabolismen_US
dc.typeArticleen_US

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