TT virus infection and genotype distribution in blood donors and a group of patients from Turkey

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dc.contributor.authorErensoy, S
dc.contributor.authorSayiner, AA
dc.contributor.authorTurkoglu, S
dc.contributor.authorCanatan, D
dc.contributor.authorAkarca, US
dc.contributor.authorSertoz, R
dc.contributor.authorOzacar, T
dc.contributor.authorBatur, Y
dc.contributor.authorBadur, S
dc.contributor.authorBilgic, A
dc.date.accessioned2019-10-27T18:43:23Z
dc.date.available2019-10-27T18:43:23Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: TT virus (TTV) DNA has been found in a Large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. Materials and Methods: TTV DNA was investigated in serum samples of 91 volunteer blood donors (BD), 105 thalassemia (TH) patients, ten patients with fulminant hepatitis (FH) and 16 hemodialysis (HD) patients by hemi-nested PCR using primers NG059, NG061 and NG063 from the ORF1 region. 39 isolates were genotyped by analyzing the partial sequence of ORF1. Results: TTV DNA was found in 75% of HD, 80% of FH, 61% of TH patients and in 51.6% of BD. Among the sequenced isolates, 14 (35.9%) belonged to genotype 1 (G1) and 25 (64.1%) belonged to genotype 2 (G2). Among the G2 sequences, 22 were grouped as G2c. Conclusion: TTV infection was common in the population studied, even with moderately sensitive primers. G2 was the major genotype of the studied population without any significant differences in distribution between various patient groups and BD.en_US
dc.identifier.doi10.1007/s15010-002-2185-zen_US
dc.identifier.endpage302en_US
dc.identifier.issn0300-8126
dc.identifier.issue5en_US
dc.identifier.pmid12382090en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.1007/s15010-002-2185-z
dc.identifier.urihttps://hdl.handle.net/11454/37212
dc.identifier.volume30en_US
dc.identifier.wosWOS:000178702500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMmv Medien & Medizin Verlagsgesellschaft Mbhen_US
dc.relation.ispartofInfectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleTT virus infection and genotype distribution in blood donors and a group of patients from Turkeyen_US
dc.typeArticleen_US

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