Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice

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dc.authoridHeidari, Reza/0000-0002-7038-9838
dc.authoridEftekhari, Aziz/0000-0003-0274-4479
dc.authoridOmmati, Mohammad Mehdi/0000-0003-0514-2414
dc.contributor.authorOmmati, Mohammad Mehdi
dc.contributor.authorNozhat, Zahra
dc.contributor.authorSabouri, Samira
dc.contributor.authorKong, Xiangdong
dc.contributor.authorRetana-Marquez, Socorro
dc.contributor.authorEftekhari, Aziz
dc.contributor.authorMa, Yanqin
dc.date.accessioned2024-08-31T07:47:40Z
dc.date.available2024-08-31T07:47:40Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractChlorpyrifos (CPF), dichlorvos (DDV), and cypermethrin (CP), as commonly used pesticides, have been implicated in inducing neuropsychiatric disorders, such as anxiety, depression-like behaviors, and locomotor activity impairment. However, the exact molecular mechanisms of these adverse effects, particularly in both sexes and their next-generation effects, remain unclear. In this study, we conducted behavioral analysis, along with cellular assays (monodansylcadaverine staining) and molecular investigations (qRT-PCR and western blotting of mTOR, P62, and Beclin-1) to clear the potential role of autophagy in pesticide-induced behavioral alterations. For this purpose, 42 adult female and 21 male inbred ICR mice (F0) were distributed into seven groups. Maternal mice (F0) and 112 F1 offspring were exposed to 0.5 and 1 ppm of CPF, DDV, and CP through drinking water. F1 male and female animals were studied to assess the sex-specific effects of pesticides on brain tissue. Our findings revealed pronounced anxiogenic effects and impaired locomotor activity in mice. F1 males exposed to CPF (1 ppm) exhibited significantly elevated depression-like behaviors compared to other groups. Moreover, pesticide exposure reduced mTOR and P62 levels, while enhancing the Beclin-1 gene and protein expression. These changes in autophagy signaling pathways, coupled with oxidative and neurogenic damage in the cerebral cortex and hippocampus, potentially contribute to heightened locomotor activity, anxiety, and depression-like behaviors following pesticide exposure. This study underscores the substantial impact of pesticides on both physiological and behavioral aspects, emphasizing the necessity for comprehensive assessments and regulatory considerations for pesticide use. Additionally, the identification of sex-specific responses presents a crucial dimension for pharmaceutical sciences, highlighting the need for tailored therapeutic interventions and further research in this field.en_US
dc.description.sponsorshipNational Natural Science Foundation of China; Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology; Pharmaceutical Sciences Research Center of Shiraz University of Medical Sciencesen_US
dc.description.sponsorshipThe authors acknowledge the Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, and the Pharmaceutical Sciences Research Center of Shiraz University of Medical Sciences for this investigation.en_US
dc.identifier.doi10.1021/acs.jafc.4c02299
dc.identifier.endpage11220en_US
dc.identifier.issn0021-8561
dc.identifier.issn1520-5118
dc.identifier.issue19en_US
dc.identifier.pmid38708789en_US
dc.identifier.scopus2-s2.0-85192979212en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11205en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jafc.4c02299
dc.identifier.urihttps://hdl.handle.net/11454/104510
dc.identifier.volume72en_US
dc.identifier.wosWOS:001225122200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectChlorpyrifosen_US
dc.subjectDichlorvosen_US
dc.subjectCypermethrinen_US
dc.subjectOrganophosphatesen_US
dc.subjectNeuropsychiatric Disordersen_US
dc.titlePesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Miceen_US
dc.typeArticleen_US

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