Isolation and identification of a new saponin from Cephalaria aytachii

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dc.contributor.authorKayce, Peyker
dc.contributor.authorKirmizigul, Suheyla
dc.date.accessioned2019-10-27T11:23:10Z
dc.date.available2019-10-27T11:23:10Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractA new hederagenin-type triterpenoid glycoside (1) named Aytachoside A, along with eight known triterpene glycosides, were isolated from the aerial parts of Cephalaria aytachii Gokturk and Sumbul (Dipsacaceae). The structures of compounds 1-9 were determined by spectroscopic (1D and 2D NMR, HRESIMS) and chemical examinations. The antimicrobial effect of compound 1 was found considerably active against Escherichia coli, Pseudomonas aeruginosa and especially Salmonella typhimurium microorganisms using the MIC method. Although compound 1 was found not to have a remarkable toxic effect at a concentration lower than 300g/mL, cytotoxic activity tests demonstrated that prosapogenin 1a exhibits a significant cytotoxic activity against HeLa cell lines using the MTT assay for the first time.en_US
dc.description.sponsorshipResearch Grant Office of Ege University Izmir-TurkeyEge University [2013/Fen/035]; Scientific and Technological Research Council of Turkey (TUBITAK) PhD Scholarship [2211-A]en_US
dc.description.sponsorshipThis work was supported by the Research Grant Office of Ege University Izmir-Turkey [grant number 2013/Fen/035]; Scientific and Technological Research Council of Turkey (TUBITAK) PhD Scholarship [grant number 2211-A].en_US
dc.identifier.doi10.1080/14786419.2016.1212029en_US
dc.identifier.endpage57en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue1en_US
dc.identifier.pmid27454791en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2016.1212029
dc.identifier.urihttps://hdl.handle.net/11454/33141
dc.identifier.volume31en_US
dc.identifier.wosWOS:000388970800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAytachoside Aen_US
dc.subjectDipsacaceaeen_US
dc.subjectCephalaria aytachiien_US
dc.subjecttriterpene saponinen_US
dc.subjectantimicrobial activityen_US
dc.subjectcytotoxic activityen_US
dc.titleIsolation and identification of a new saponin from Cephalaria aytachiien_US
dc.typeArticleen_US

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