The Comparison of Reported Ingested Paracetamol Dose with Serum Blood Concentrations and Their Relationship with N-Acetylcysteine Administration: A Retrospective Study of 117 Patients

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dc.authorscopusid57194763753
dc.authorscopusid41662339000
dc.authorscopusid57217052353
dc.authorscopusid37076963100
dc.authorscopusid58309033700
dc.authorscopusid36127430300
dc.authorscopusid35312096900
dc.contributor.authorTuran, C.
dc.contributor.authorYurtseven, A.
dc.contributor.authorBasa, E.G.
dc.contributor.authorErgin, F.
dc.contributor.authorUçar, M.
dc.contributor.authorKarakoyun, M.
dc.contributor.authorSaz, E.U.
dc.date.accessioned2024-08-25T18:51:52Z
dc.date.available2024-08-25T18:51:52Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: We aimed to compare the patient reported ingested and blood paracetamol concentrations (BPC) and to investigate the indications for N-acetylcysteine (NAC) administration in referred patients. Methods: This is a retrospective study of acute paracetamol intoxications (API) at the tertiary paediatric emergency department (ED) between June 2015-June 2019. We evaluated the demographics, cause of intoxications, reported doses (mg/kg), BPCs (8/4/12/16 and/or 24th hours). Indications of antidote usage and referral to ED were accepted as BPC >150 mg/kg. Results: Overall, we reviewed 117 cases of acute API. The mean age was 8.97 (±6.0) years, and 68.3% were female. The reported ingested of paracetamol (RIP) median dose was 2725 mg (mean 138±51.9 mg/kg). Adolescents had a significantly higher RIP than that of younger subjects (p<0.001). BPC was performed in 88.9% of the patients at the 4th, 8th, 12th, 16th and 24th hour in 11.1%, 9.4%, 3.5% and 3.5% of cases, respectively. Although, only 34/66 of the referred cases had a RIP dose >150 mg/kg, physicians at the first healthcare facility tended to administer activated charcoal (90.9%), gastric lavage (68%) and intravenous NAC (48%). The referring healthcare facility physicians-initiated NAC particularly for patients who reported ingesting >150 mg/kg (p=0.001). Conclusion: RIP doses should not be used to determine the need for NAC. The antidote should be used in centres where BPCs are not available or in a group of patients who cannot be transferred to a referral centre within the first eight hours. © 2023, Galenos Publishing House. All rights reserved.en_US
dc.description.sponsorshipEge Üniversitesien_US
dc.description.sponsorshipWe are grateful to Ege University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentation for their support in editing and proofreading service of this study.en_US
dc.identifier.doi10.4274/cayd.galenos.2022.59454
dc.identifier.endpage110en_US
dc.identifier.issn2717-9206
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85161371061en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage104en_US
dc.identifier.trdizinid1181203en_US
dc.identifier.urihttps://doi.org/10.4274/cayd.galenos.2022.59454
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1181203
dc.identifier.urihttps://hdl.handle.net/11454/102733
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofJournal of Pediatric Emergency and Intensive Care Medicine(Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectacetaminophenen_US
dc.subjectchildrenen_US
dc.subjectintoxicationen_US
dc.subjectN-acetylcysteineen_US
dc.subjectParacetamolen_US
dc.titleThe Comparison of Reported Ingested Paracetamol Dose with Serum Blood Concentrations and Their Relationship with N-Acetylcysteine Administration: A Retrospective Study of 117 Patientsen_US
dc.title.alternativeAlındığı İddia Edilen Parasetamol Dozunun Kan Düzeyleri ile Karşılaştırılması ve N-Asetilsistein Parasetamol Kullanımı ile İlişkisi: 117 Hasta ile Geriye Dönük Bir Çalışmaen_US
dc.typeArticleen_US

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