Oxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental model

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dc.contributor.authorHortu, Ismet
dc.contributor.authorKaradadas, Elif
dc.contributor.authorOzceltik, Gokay
dc.contributor.authorTavmergen, Erol
dc.contributor.authorTavmergen Goker, Ege Nazan
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.date.accessioned2020-12-01T11:57:45Z
dc.date.available2020-12-01T11:57:45Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose Ovarian hyperstimulation syndrome (OHSS) is a life-threatening complication of ovarian stimulation in reproductive medicine. Here, we aimed to investigate the role of oxytocin (OT) and cabergoline in the prevention and alleviation of the OHSS in an animal model. Methods Thirty-five female immature Wistar rats were randomly assigned to five groups. the control group (n = 7) received saline only for five consecutive days. Remaining twenty-eight rats received 10 IU of pregnant mare serum gonadotropin (PMSG) followed by 30 IU of human chorionic gonadotropin (hCG) to induce OHSS. Group 2 (n = 7) was managed with no additional intervention after the induction of OHSS. Group 3 (n = 7) received 100 mu g/kg cabergoline 2 h before the PMSG injection for four consecutive days and 2 h before the hCG injection on the fifth day. Group 4 (n = 7) and group 5 (n = 7) received 80 mu g/kg and 160 mu g/kg OT after induction of OHSS, respectively. Oxytocin was administered 2 h before the PMSG injection for four consecutive days and 2 h before the hCG injection on the fifth day. Body and ovary weight, vascular permeability (VP), VEGF expression in the ovaries, and levels of VEGF in the peritoneal fluids were examined in all animals. Results Cabergoline and OT reduced body weight, ovary weight, and VP compared to that of the OHSS group (p < 0.05). VEGF expressions in ovaries and peritoneal VEGF levels were decreased in cabergoline and OT groups compared to that of the OHSS groups (p < 0.001 for cabergoline and OT-80 mu g/kg; p < 0.00001 for OT-160 mu g/kg). However, there was no statistically significant difference in these parameters between the OT and cabergoline groups. Conclusion Both OT and cabergoline were active in the alleviation of OHSS through suppression of VEGF and VP. Overall, we conclude that OT is effective for downregulation for VEGF and improvement in vascular permeability in OHSS.en_US
dc.identifier.doi10.1007/s00404-020-05855-1en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.pmid33140116en_US
dc.identifier.scopus2-s2.0-85094855849en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-020-05855-1
dc.identifier.urihttps://hdl.handle.net/11454/61792
dc.identifier.wosWOS:000584341600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian hyperstimulation syndromeen_US
dc.subjectVEGFen_US
dc.subjectOxytocinen_US
dc.subjectCabergolineen_US
dc.subjectAnimal modelen_US
dc.titleOxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental modelen_US
dc.typeArticleen_US

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