Can we define any marker associated with brain failure in patients with locally advanced non-small cell lung cancer?

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dc.authoridYalman, Deniz/0000-0002-4010-8353
dc.authorwosidYalman, Deniz/ABG-5077-2020
dc.contributor.authorSert, F.
dc.contributor.authorCosgun, G.
dc.contributor.authorYalman, D.
dc.contributor.authorOzkok, S.
dc.date.accessioned2023-01-12T19:54:30Z
dc.date.available2023-01-12T19:54:30Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose. - To define the factors which may be related to brain metastasis (BM) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who developed brain metastases after definitive treatment. Patients and methods. - A total of 208 patients with LA-NSCLC, without BM who received definitive radiotherapy (RT) or RT + chemotherapy (CT) between January 2005 and January 2016 were evaluated retrospectively. Platelet, neutrophil, lymphocyte counts, LDH, CRP, Hb levels, neutrophil-to-lymphocyte radio (NLR), platelet-to-lymphocyte radio (PLR), advanced lung cancer inflammation index (ALI) and FDG-PET/CT parameters (SUVmax of the primary tumor and mediastinal lymph nodes), and patient characteristics were evaluated for brain metastasis free survival (BMFS). Results. - Median follow-up duration was 25 months (range: 3-130 months). Cut-off values for platelet, NLR, PLR, LDH, CRP, and Hb were 290 x 103/mu L, 2.6, 198, 468 IU/L, 2.5 mg/dL, and 11.5 g/d1. We defined each parameter as low or high according to the cut-off values. 56 patients (26.9%) developed brain metastases during follow-up. In univariate analysis, high NLR (P=0.001), PLR (P=0.037), LDH (P = 0.028), CRP (P = 0.002) values, value >= 7.5 for lymph nodes (P = 0.005) and low ALI value (P = 0.002) were poor prognostic factors for BMFS. In multivariate analysis, high NLR (P= 0.022), PLR (P= 0.017), CRP (P= 0.006), stage >= IIIB disease (P< 0.001), multi-stational N2 disease (P= 0.036), adenocarcinoma histology (P< 0.001) and SUVmax value >= 7.5 (P = 0.035) were poor prognostic factors for BMFS. Conclusions. - High NLR, PLR, LDH, CRP values, SUVmax values for lymph nodes, and low ALI which indicates high tumor burden were additional prognostic factors besides stage, histology, and lymph node status. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.canrad.2020.11.002
dc.identifier.endpage322en_US
dc.identifier.issn1278-3218
dc.identifier.issn1769-6658
dc.identifier.issue4en_US
dc.identifier.pmid33422415en_US
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.1016/j.canrad.2020.11.002
dc.identifier.urihttps://hdl.handle.net/11454/76444
dc.identifier.volume25en_US
dc.identifier.wosWOS:000656542700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCancer Radiotherapieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProphylactic cranial irradiationen_US
dc.subjectPredictive markersen_US
dc.subjectLung canceren_US
dc.subjectNon-small cell lung canceren_US
dc.subjectProphylactic Cranial Irradiationen_US
dc.subjectTo-Lymphocyte Ratioen_US
dc.subjectPrognostic-Significanceen_US
dc.subjectPoor Survivalen_US
dc.subjectRisk-Factorsen_US
dc.subjectMetastasesen_US
dc.subjectInflammationen_US
dc.subjectPlateleten_US
dc.titleCan we define any marker associated with brain failure in patients with locally advanced non-small cell lung cancer?en_US
dc.typeArticleen_US

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