Dysembryoplastic neuroepithelial tumors of childhood: Ege University experience

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dc.authoridAtaseven, eda/0000-0003-3419-5814
dc.authorscopusid56270845700
dc.authorscopusid57219271662
dc.authorscopusid57729247600
dc.authorscopusid57201184233
dc.authorscopusid12753401700
dc.authorscopusid6601965962
dc.authorscopusid55968773100
dc.authorwosidAtaseven, Eda/AAB-3390-2022
dc.authorwosidKantar, Mehmet/ABF-5225-2022
dc.contributor.authorAtaseven, Eda
dc.contributor.authorOzcan, Muhittin
dc.contributor.authorOlculu, Cemile Busra
dc.contributor.authorBolat, Elif
dc.contributor.authorErtan, Yesim
dc.contributor.authorKitis, Omer
dc.contributor.authorTekgul, Hasan
dc.date.accessioned2023-01-12T19:50:09Z
dc.date.available2023-01-12T19:50:09Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground Dysembryoplastic neuroepithelial tumors (DNETs) are rare, low-grade tumors of the central nervous system (CNS) of childhood. It is an important cause of intractable epilepsy, and it is surgically curable. We aimed to review our institutional experience with DNET in children. Methods Medical records of children aged less than 18 years of age diagnosed with DNET between 2009 and 2020 at Ege University Hospital were reviewed. Clinical features of the patients including age, gender, initial symptoms, duration of symptoms, medical treatments, age at the time of surgery, tumor location, degree of surgical resection, and outcome of the patients were documented. Results We reviewed the records of 17 patients with DNETs. Twelve of them were male (70%), 5 of them female (30%). The median age was 11 years (19 months-17 years). The major symptom was a seizure in all of the patients. Thirteen patients presented with complex partial seizures, whereas 2 had a simple partial seizure, and 2 generalized tonic-clonic seizures. Seven patients had drug resistant epilepsy and had received at least two anti-epileptic drugs before surgery. The median duration of symptoms was 6.6 months (0-48 months). In surgery, total surgical resection was performed in 15 patients, and 2 patients underwent partial resection. From these 15 patients, seven patients underwent lesionectomy of the tumor while the other eight patients had extended lesionectomy. The mean follow-up time was 107 months (54-144 months), the seizure control was achieved in 14 patients (82.4%) after surgery, but 3 patients experienced tumor recurrence in the follow-up. Conclusion In DNETs, the complete total resection of the lesion is generally associated with seizure-free outcomes. In the patients with partial resection and lesionectomy, MRI follow-up is recommended for recurrence.en_US
dc.identifier.doi10.1007/s00381-022-05565-w
dc.identifier.endpage1706en_US
dc.identifier.issn0256-7040
dc.identifier.issn1433-0350
dc.identifier.issue9en_US
dc.identifier.pmid35666284en_US
dc.identifier.scopus2-s2.0-85131451492en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1699en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-022-05565-w
dc.identifier.urihttps://hdl.handle.net/11454/76029
dc.identifier.volume38en_US
dc.identifier.wosWOS:000806721000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDysembriyoplastic neuroepithelial tumoren_US
dc.subjectEpilepsyen_US
dc.subjectSurgeryen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectEpilepsy Surgeryen_US
dc.subjectChildrenen_US
dc.subjectClassificationen_US
dc.subjectProposalen_US
dc.subjectOutcomesen_US
dc.subjectSeriesen_US
dc.titleDysembryoplastic neuroepithelial tumors of childhood: Ege University experienceen_US
dc.typeArticleen_US

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