Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five years

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dc.contributor.authorCeyhan M.
dc.contributor.authorKaradag-Oncel E.
dc.contributor.authorHascelik G.
dc.contributor.authorUstundag G.
dc.contributor.authorGurbuz V.
dc.contributor.authorSamlioglu P.
dc.contributor.authorOz F.N.
dc.date.accessioned2021-05-03T20:56:56Z
dc.date.available2021-05-03T20:56:56Z
dc.date.issued2021
dc.description.abstractPurpose: In Turkey, pneumococcal conjugate vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aim of the study was to demonstrate the pneumococcal carriage rate and the serotype distribution in healthy children under 5 years in Turkey who were vaccinated with PCV13. Methods: We conducted a cross-sectional study including the collection of questionnaire data and nasopharyngeal (NP) specimens among children aged <5 years from five centers from March 2019 to March 2020. Pneumococcal isolates were identified using optochin sensitivity and bile solubility. Serotyping was performed using a latex agglutination kit and Quellung reaction. Results: NP swab samples were collected from 580 healthy children. The observed overall carriage rate was 17.8%. None of the hypothesised predictors of S. pneumoniae carriage, except maternal education level was statistically significant (p = 0.017). High maternal education level appeared to decrease the risk (lower vs. higher maternal education OR: 1.992 [95% CI; 1.089–3.643], p = 0.025). The overall NP S. pneumoniae carriage prevalence for the PCV13-vaccinated children was 17.8% (103/580). The most common serotypes detected were serotype 15B (n = 10, 9.7%), serotype 23F (n = 9, 8.7%), serotype 23A (n = 9, 8.7%), serotype 11A (n = 7, 6.7%), serotype 19F (n = 5, 4.8%) and serotype 15F (n = 5, 4.8%). Of the isolates, 28 (27.2%) were in PCV13 vaccine strains (VSs), and 75 (72.8%) strains were non-VS. The serotype coverage rate was 27.2% for PCV13. Conclusion: The overall S. pneumoniae carriage rate was higher than in earlier studies from Turkey. Post-vaccine era studies from around the world have reported a decrease in VS serotypes and a ‘serotype replacement’ to non-VS serotypes, as we determined in our study. © 2021 Elsevier Ltden_US
dc.description.sponsorshipWe are grateful to Ferhan Elmal?, Department of Biostatistics, Izmir Katip ?elebi University for his help in the statistical analysis. All authors attest they meet the ICMJE criteria for authorship.en_US
dc.identifier.doi10.1016/j.vaccine.2021.03.028en_US
dc.identifier.endpage2047en_US
dc.identifier.issn0264-410X
dc.identifier.issue15en_US
dc.identifier.pmid33741188en_US
dc.identifier.scopus2-s2.0-85102731360en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2041en_US
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2021.03.028
dc.identifier.urihttps://hdl.handle.net/11454/71432
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofVaccineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHealthy childrenen_US
dc.subjectNasopharyngeal carriageen_US
dc.subjectPost-vaccinationen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectTurkeyen_US
dc.titleNasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five yearsen_US
dc.typeArticleen_US

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