Reference ranges of presepsin (soluble CD14 subtype) in term and preterm neonates without infection, in relation to gestational and postnatal age, in the first 28 days of life

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dc.contributor.authorErgor, Serap Nur
dc.contributor.authorYalaz, Mehmet
dc.contributor.authorKoroglu, Ozge Altun
dc.contributor.authorSozmen, Eser
dc.contributor.authorAkisu, Mete
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2020-12-01T12:02:19Z
dc.date.available2020-12-01T12:02:19Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To determine the reference ranges of presepsin in term and preterm neonates without infection, with respect to gestational and postnatal age, within the first 28 days of life. Methods: A total of 144 neonates born at 24-42 weeks' gestation, including healthy term and preterm neonates without clinical signs or symptoms of infection, were included in this prospective observational study. Presepsin measurements included cord blood levels and serum levels on postnatal days 1, 3, 5, 7, 14, 21, and 28. Results: the presepsin values corresponding to the 10th percentile ranged from 240.8 pg/mL (on day 1) to 129.9 pg/mL (on day 28), whereas those corresponding to the 90th percentile ranged from 725.8 pg/mL (on day 1) to 471.6 pg/mL (on day 28). Significantly higher presepsin levels were observed in cesarean deliveries than in spontaneous deliveries (p: 0.012 to < 0.001), in gestational ages <= 32 weeks than in gestational ages >= 37 weeks (p: < 0.05 to < 0.001), and in cases with a maternal history of chorioamnionitis than in those without (p: < 0.05 to < 0.001). Conclusion: in conclusion, our findings revealed, for the first time, the reference ranges of presepsin in healthy term and preterm neonates without infection with respect to gestational and postnatal age, sex, and body weight. Presepsin levels within the first 28 days of life seem likely to be affected by the type of delivery, gestational and postnatal age, birth weight, and presence of respiratory distress syndrome or maternal chorioamnionitis.en_US
dc.identifier.doi10.1016/j.clinbiochem.2019.12.007en_US
dc.identifier.endpage13en_US
dc.identifier.issn0009-9120
dc.identifier.issn1873-2933
dc.identifier.pmid31843667en_US
dc.identifier.scopus2-s2.0-85077152593en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2019.12.007
dc.identifier.urihttps://hdl.handle.net/11454/62650
dc.identifier.volume77en_US
dc.identifier.wosWOS:000514832200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPresepsinen_US
dc.subjectReference rangesen_US
dc.subjectTerm neonatesen_US
dc.subjectPreterm neonatesen_US
dc.subjectPostnatal ageen_US
dc.titleReference ranges of presepsin (soluble CD14 subtype) in term and preterm neonates without infection, in relation to gestational and postnatal age, in the first 28 days of lifeen_US
dc.typeArticleen_US

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