EVALUATION OF THE ROLE OF EPSTEIN-BARR VIRUS IN CASES OF NODAL OR EXTRANODAL T- AND NK-CELL LYMPHOMA USING EBER IN SITU HYBRIDIZATION

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dc.contributor.authorKaraarslan, Serap
dc.contributor.authorHekimgil, Mine
dc.contributor.authorSoydan, Saliha
dc.contributor.authorErtan, Yesim
dc.contributor.authorDoganavsargil, Basak
dc.date.accessioned2019-10-27T22:59:51Z
dc.date.available2019-10-27T22:59:51Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractVarious racial and geographic differences have been observed in studies questioning the role of Epstein-Barr virus (EBV) infection in the etiology of T- and NK-cell lymphomas. The aim of this study was to evaluate the relationship of EBV with nodal or extranodal (skin excluded) T- and NK-cell lymphoma subtypes encountered in our geographic area. Sixty-two cases of peripheral T-cell lymphoma were included in the study. EBV-encoded early RNA (EBER) was detected by in situ hybridization. The distributions of T- and NK-cell lymphoma subtypes were as follows: 32 peripheral T-cell lymphomas, unspecified (PTCL, NOS), 13 anaplastic large-cell lymphomas (ALCL), 8 angioimmunoblastic T-cell lymphomas (AITCL), 4 extranodal NK/T-cell lymphomas, nasal type (NKTCL), 3 enteropathy-type T-cell lymphomas (ETTCL), 1 hepatosplenic T-cell lymphoma (HSTCL), and 1 subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Using a cut-off value of > 25% of EBER-positive neoplastic lymphoid cells, EBV was positive in 22.6% of all cases. According to subtype, the neoplastic cells of 31.3% of PTCL, NOS and 100% of extranodal NKTCL, nasal type were EBER positive, whereas some cases of ALCL, AITCL, and ETTCL presented EBER-positive non-neoplastic cells, and all cells of HSTCL and SPTCL were EBV negative. Extranodal NKTCL, nasal type, presented the strongest association with EBV, followed by PTCL, NOS.en_US
dc.identifier.doi10.5114/PJP.2015.53013en_US
dc.identifier.endpage169en_US
dc.identifier.issn1233-9687
dc.identifier.issue2en_US
dc.identifier.pmid26247530en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2015.53013
dc.identifier.urihttps://hdl.handle.net/11454/51894
dc.identifier.volume66en_US
dc.identifier.wosWOS:000358822800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlymphomaen_US
dc.subjectT-cellen_US
dc.subjectextranodal NK-T-cellen_US
dc.subjectEBVen_US
dc.subjectEBERen_US
dc.subjectin situ hybridizationen_US
dc.titleEVALUATION OF THE ROLE OF EPSTEIN-BARR VIRUS IN CASES OF NODAL OR EXTRANODAL T- AND NK-CELL LYMPHOMA USING EBER IN SITU HYBRIDIZATIONen_US
dc.typeArticleen_US

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