Coexistence of Primary Hyperparathyroidism and Differentiated Thyroid Carcinoma: Is It a Coincidence?

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dc.authorscopusid55753879900
dc.authorscopusid56779792800
dc.authorscopusid57950049100
dc.authorscopusid6603166584
dc.authorscopusid12545052400
dc.authorscopusid26022436600
dc.contributor.authorBaykan, Emine Kartal
dc.contributor.authorBaykan, Ahmed Ramiz
dc.contributor.authorSakarya, Mehmet Hamdi
dc.contributor.authorBilici, Ahmet Erkan
dc.contributor.authorKurt, Ali
dc.contributor.authorErdogan, Mehmet
dc.date.accessioned2023-01-12T20:18:44Z
dc.date.available2023-01-12T20:18:44Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Coexistence of primary hyperparathyroidism and differentiated thyroid carcinoma has been reported from time to time. However, the clinical features and risk factors of this association are unclear. In this study, we aimed to evaluate the relationship between primary hyperparathyroidism and differentiated thyroid carcinoma. Methods: The files of patients who were diagnosed with parathyroid adenoma and underwent parathyroid surgery in the endocrinology outpatient clinic between January 2015 and June 2021 were reviewed retrospectively. The clinical signs, biochemical abnormalities, and histological features of the patients were analyzed. Results: This study included 255 patients who were operated on with the diagnosis of parathyroid adenoma. When the ultrasonography reports of the patients were evaluated, thyroid nodules were detected in 100/255 (39.2%) patients. When the postoperative histology of the patients was evaluated, differentiated thyroid carcinoma was detected in 35/255 (13.7%) patients. Parathormone and calcium levels were found to be significantly lower in patients with differentiated thyroid carcinoma compared to patients with benign thyroid nodules (P <.05). In logistic regression analysis, there was a significant correlation between the presence of differentiated thyroid carcinoma and low serum calcium level (odds ratio: 0.031; 95% CI: 0.001-0.654; P =.035). In the receiver operating characteristic curve analysis, we found that serum calcium level <11.05 mg/dL in patients with parathyroid adenoma has good capacity to differentiate differentiated thyroid carcinoma from benign thyroid nodule (area under the curve: 0.648, P =.032, 71.4% sensitivity, and 72.7% specificity). Conclusion: We can say that the incidence of thyroid nodules increases in parathyroid adenoma compared to the general population and the probability of differentiated thyroid carcinoma increases as the calcium level decreases in these nodules.en_US
dc.identifier.doi10.5152/tjem.2022.22043
dc.identifier.endpage124en_US
dc.identifier.issn1301-2193
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85141095628en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage120en_US
dc.identifier.trdizinid1124135en_US
dc.identifier.urihttps://doi.org/10.5152/tjem.2022.22043
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124135
dc.identifier.urihttps://hdl.handle.net/11454/78897
dc.identifier.volume26en_US
dc.identifier.wosWOS:000861099600004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Endocrinology And Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalciumen_US
dc.subjectparathyroid adenomaen_US
dc.subjectthyroid canceren_US
dc.subjectSerum-Calciumen_US
dc.subjectCancer-Risken_US
dc.subjectAssociationen_US
dc.titleCoexistence of Primary Hyperparathyroidism and Differentiated Thyroid Carcinoma: Is It a Coincidence?en_US
dc.typeArticleen_US

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