Autoimmune thyroid disease in ankylosing spondylitis

Basit Öğe Kaydı
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorKalfa, Melike
dc.contributor.authorKarabulut, Gonca
dc.contributor.authorKocanaogullari, Hayriye
dc.contributor.authorInal, Vedat
dc.contributor.authorAksu, Kenan
dc.contributor.authorOksel, Fahrettin
dc.contributor.authorKabasakal, Yasemin
dc.contributor.authorKeser, Gokhan
dc.date.accessioned2019-10-27T22:14:14Z
dc.date.available2019-10-27T22:14:14Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractAlthough autoimmune thyroid disease is well known to be associated with primary Sjogren's syndrome (SjS) and with various autoimmune diseases, it is less clear whether a similar association also exists for ankylosing spondylitis (AS). Therefore, we investigated the frequency of autoimmune thyroid disease in patients with AS. In this cross sectional study, 80 patients with AS fulfilling the 1984 Modified New York Criteria and 80 healthy subjects, age and sex-matched with AS patients, were included. As the positive control group, 62 female patients with primary SjS were also studied. All cases underwent thyroid ultrasonography (USG) by a single endocrinologist. Thyroid function tests and thyroid autoantibodies were measured. The diagnosis of Hashimoto's thyroiditis (HT) was made if the patient had thyroid autoantibody positivity plus at least one of the following criteria: diffuse goiter with physical examination, abnormality in thyroid function tests, and parenchymal heterogeneity with USG. The chi-squared test and Fisher's exact test were used to compare cases and controls. The p values < 0.05 were considered statistically significant. The frequencies of parenchymal heterogeneity with USG (30 vs 11.3 %, p = 0.045), thyroid autoantibody positivity (13.8 vs 2.5 %, p = 0.017), and concomitant diagnosis of HT (10 vs 1.3 %, p = 0.034) were significantly higher in AS group compared to healthy controls. Among AS patients having HT, subclinical hypothyroidism was detected only in a single patient. Frequency of autoimmune thyroid disease was significantly higher in AS group, compared to healthy controls. Prospective studies are needed to see the clinical relevance of these findings and outcome in the long term.en_US
dc.identifier.doi10.1007/s10067-013-2466-1en_US
dc.identifier.endpage961en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue7en_US
dc.identifier.pmid24384825en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage955en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-013-2466-1
dc.identifier.urihttps://hdl.handle.net/11454/49967
dc.identifier.volume33en_US
dc.identifier.wosWOS:000338324000011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectAutoimmune thyroid diseaseen_US
dc.subjectHashimoto's thyroiditisen_US
dc.subjectThyroid autoantibodyen_US
dc.subjectThyroid hypoechogenicityen_US
dc.titleAutoimmune thyroid disease in ankylosing spondylitisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu