Diagnostic Potential of Autophagy-5 Protein, Apolipoprotein B-48, and Oxidative Stress Markers in Serum of Patients with Early-Stage Ischemic Stroke

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dc.authoridAjoolabady, Amir/0000-0002-3667-2605
dc.authoridNourazarian, Alireza/0000-0003-2082-1335
dc.authorscopusid57211579985
dc.authorscopusid57216431373
dc.authorscopusid57212299393
dc.authorscopusid8951159600
dc.authorscopusid55565668500
dc.authorscopusid57209237133
dc.authorwosidNourazarian, Alireza/G-3873-2015
dc.contributor.authorAjoolabady, Amir
dc.contributor.authorShademan, Behrouz
dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorNikanfar, Masoud
dc.contributor.authorNourazarian, Alireza
dc.contributor.authorLaghousi, Delara
dc.date.accessioned2023-01-12T19:58:28Z
dc.date.available2023-01-12T19:58:28Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstract-OBJECTIVE: Strokes are among the leading causes of death worldwide and have different characteristics. Different physiopathological mechanisms characterize the -umerous subtypes of ischemic stroke (IS). In this study, we investigated the relationship between serum levels of autophagy-5 protein, apolipoprotein B-48, and oxidative stress markers in patients with ischemic stroke.-METHODS: For this study, 100 participants were recruited, of which 50 were patients with IS and 50 were healthy individuals. We conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. Serum levels of ATG5, apo B-48, and oxidative stress markers were determined in both groups. Our Receiver Operating Characteristic Analysis evaluated the additional diagnostic value of these factors in both groups. -RESULTS: Diabetes, smoking, age, sex, alcohol con-sumption, weight, and height did not differ significantly between the 2 groups (P > 0.05). However, the 2 groups had significant differences in hypertension and body mass in-dex (P < 0.05). Fifty-four percent (27 patients) of patients with IS had an ischemic stroke in large vessels, while 46% (23 patients) had an ischemic stroke in small vessels. Serum levels of ATG5, apo B-48, and oxidative stress markers were higher in the case group than in the control group (P< 0.0001).-CONCLUSIONS: In patients with IS, serum levels of ATG5, apoB-48, malonaldehyde, total oxidative stress, and total antioxidant capacity can be used as novel biomarkers to predict or treat the disease.en_US
dc.description.sponsorshipTabriz University of Medical Sciences, Tabriz, IRAN [IR.TBZMED.REC.1399.879]en_US
dc.description.sponsorshipThis work was supported by a grant from the Vice Chancellor for Research, Tabriz University of Medical Sciences, Tabriz, IRAN. The grant number is IR.TBZMED.REC.1399.879.en_US
dc.identifier.doi10.1016/J.WNEU.2022.08.063
dc.identifier.endpageE663en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid36030010en_US
dc.identifier.scopus2-s2.0-85138050379en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE656en_US
dc.identifier.urihttps://doi.org/10.1016/J.WNEU.2022.08.063
dc.identifier.urihttps://hdl.handle.net/11454/76915
dc.identifier.volume167en_US
dc.identifier.wosWOS:000886717100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApolipoprotein B-48en_US
dc.subjectAutophagy 5-proteinen_US
dc.subjectIschemic strokeen_US
dc.subjectOxidative stressen_US
dc.subjectInjuryen_US
dc.titleDiagnostic Potential of Autophagy-5 Protein, Apolipoprotein B-48, and Oxidative Stress Markers in Serum of Patients with Early-Stage Ischemic Strokeen_US
dc.typeArticleen_US

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