Association between vitamin D receptor gene FokI polymorphism and mortality in patients with sepsis

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dc.authoridkilincer bozgül, sukriye miray/0000-0002-3995-5096
dc.authoridCan, Özge/0000-0003-3220-5994
dc.authoridKarbek Akarca, Funda/0000-0003-2455-8044
dc.authoridATIK, TAHIR/0000-0002-1142-3872
dc.contributor.authorBozgul, Sukriye Miray Kilincer
dc.contributor.authorEmecen, Durdugul Ayyildiz
dc.contributor.authorAkarca, Funda Karbek
dc.contributor.authorBozkurt, Devrim
dc.contributor.authorAydin, Ozgur
dc.contributor.authorKoca, Didem
dc.contributor.authorCan, Ozge
dc.date.accessioned2024-08-31T07:50:20Z
dc.date.available2024-08-31T07:50:20Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Sepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Conclusion The VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.en_US
dc.description.sponsorshipEge University Scientific Project Unit [TGA-2020-22223]en_US
dc.description.sponsorshipThis work was supported by Ege University Scientific Project Unit ( Grant Number: TGA-2020-22223)en_US
dc.identifier.doi10.1007/s11033-023-08971-8
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1en_US
dc.identifier.pmid38158430en_US
dc.identifier.scopus2-s2.0-85181210155en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-023-08971-8
dc.identifier.urihttps://hdl.handle.net/11454/105198
dc.identifier.volume51en_US
dc.identifier.wosWOS:001132269100008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSepsisen_US
dc.subjectFokien_US
dc.subjectPolymorphismen_US
dc.subjectMortalityen_US
dc.subjectVitamin D Receptoren_US
dc.titleAssociation between vitamin D receptor gene FokI polymorphism and mortality in patients with sepsisen_US
dc.typeArticleen_US

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