Nonionic, water self-dispersible "hairy-Rod" poly(p -phenylene)-g-poly(ethylene glycol) copolymer/carbon nanotube conjugates for targeted cell imaging

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dc.contributor.authorYuksel M.
dc.contributor.authorColak D.G.
dc.contributor.authorAkin M.
dc.contributor.authorCianga I.
dc.contributor.authorKukut M.
dc.contributor.authorMedine E.I.
dc.contributor.authorCan M.
dc.contributor.authorSakarya S.
dc.contributor.authorUnak P.
dc.contributor.authorTimur S.
dc.contributor.authorYagci Y.
dc.date.accessioned2019-10-26T21:43:57Z
dc.date.available2019-10-26T21:43:57Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractThe generation and fabrication of nanoscopic structures are of critical technological importance for future implementations in areas such as nanodevices and nanotechnology, biosensing, bioimaging, cancer targeting, and drug delivery. Applications of carbon nanotubes (CNTs) in biological fields have been impeded by the incapability of their visualization using conventional methods. Therefore, fluorescence labeling of CNTs with various probes under physiological conditions has become a significant issue for their utilization in biological processes. Herein, we demonstrate a facile and additional fluorophore-free approach for cancer cell-imaging and diagnosis by combining multiwalled CNTs with a well-known conjugated polymer, namely, poly(p-phenylene) (PP). In this approach, PP decorated with poly(ethylene glycol) (PEG) was noncovalently (?-? stacking) linked to acid-treated CNTs. The obtained water self-dispersible, stable, and biocompatible f-CNT/PP-g-PEG conjugates were then bioconjugated to estrogen-specific antibody (anti-ER) via -COOH functionalities present on the side-walls of CNTs. The resulting conjugates were used as an efficient fluorescent probe for targeted imaging of estrogen receptor overexpressed cancer cells, such as MCF-7. In vitro studies and fluorescence microscopy data show that these conjugates can specifically bind to MCF-7 cells with high efficiency. The represented results imply that CNT-based materials could easily be fabricated by the described approach and used as an efficient "fluorescent probe" for targeting and imaging, thereby providing many new possibilities for various applications in biomedical sensing and diagnosis. © 2012 American Chemical Society.en_US
dc.identifier.doi10.1021/bm3006193en_US
dc.identifier.endpage2691en_US
dc.identifier.issn1525-7797
dc.identifier.issue9en_US
dc.identifier.pmid22866988en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2680en_US
dc.identifier.urihttps://doi.org/10.1021/bm3006193
dc.identifier.urihttps://hdl.handle.net/11454/18429
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBiomacromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNonionic, water self-dispersible "hairy-Rod" poly(p -phenylene)-g-poly(ethylene glycol) copolymer/carbon nanotube conjugates for targeted cell imagingen_US
dc.typeArticleen_US

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