The Role of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as an Early Indicator of Mortality in Pediatric Septic Shock

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dc.authoridYazıcı Özkaya, Pınar/0000-0002-1209-2534
dc.contributor.authorTuran, Caner
dc.contributor.authorYurtseven, Ali
dc.contributor.authorOzkaya, Pinar Yazici
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorSaz, Eylem Ulas
dc.date.accessioned2024-08-31T07:47:21Z
dc.date.available2024-08-31T07:47:21Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Despite advancements in antibiotic therapy and resuscitation protocols, sepsis and septic shock remain major contributors to morbidity and mortality in children. We aimed to investigate the utility of soluble urokinase plasminogen activator receptor (suPAR) for the early detection of septic shock and to evaluate its accuracy in predicting mortality. Methods: A prospective study was conducted in a tertiary pediatric emergency department (ED), enrolling patients diagnosed with the sepsis, severe sepsis, or septic shock. In addition to assessing infection biomarkers such as C-reactive protein and procalcitonin, suPAR levels were quantified upon admission using enzyme-linked immunosorbent assay. The primary outcome measure was 30-day mortality. Results: Overall 72 patients and 80 healthy children included. Plasma suPAR levels demonstrated a statistically significant elevation in the sepsis, severe sepsis, and septic shock groups compared with the control group (p < 0.001 for all). The septic shock group exhibited the highest suPAR levels upon admission, surpassing both the sepsis and severe sepsis groups (p = 0.009 and 0.042). ROC analysis underscored the promising potential of suPAR with an AUC of 0.832 for septic shock. Analysis of mortality prediction revealed significantly higher suPAR levels in nonsurvivors than survivors (9.7 ng/mL vs. 4.2 ng/mL; p < 0.001). Employing plasma suPAR levels to discriminate between mortality and survival, a threshold of >= 7.0 ng/mL demonstrated a sensitivity of 90.9% and specificity of 71.0%. Conclusion: Plasma suPAR levels have the potential as a biomarker for predicting mortality in children with septic shock. In pediatric septic shock, the presence of plasma suPAR >= 7 ng/mL along with an underlying disease significantly increases the risk of mortality.en_US
dc.description.sponsorshipEge University Research Foundationen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1002/jcla.25040
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue9en_US
dc.identifier.pmid38708489en_US
dc.identifier.scopus2-s2.0-85192200474en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.25040
dc.identifier.urihttps://hdl.handle.net/11454/104398
dc.identifier.volume38en_US
dc.identifier.wosWOS:001214241600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectBiomarkeren_US
dc.subjectChildrenen_US
dc.subjectSepsisen_US
dc.subjectSeptic Shocken_US
dc.subjectSuparen_US
dc.titleThe Role of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as an Early Indicator of Mortality in Pediatric Septic Shocken_US
dc.typeArticleen_US

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