First-Drug Efficacy and Drug-Resistant Epilepsy Rates in Children With New-Onset Epilepsies: A Multicenter Large Cohort Study

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dc.contributor.authorGencpinar, Pinar
dc.contributor.authorArican, Pinar
dc.contributor.authorDundar, Nihal Olgac
dc.contributor.authorKilic, Betul
dc.contributor.authorSarigecili, Esra
dc.contributor.authorOkuyaz, Cetin
dc.contributor.authorTekgul, Hasan
dc.date.accessioned2025-05-06T13:20:54Z
dc.date.available2025-05-06T13:20:54Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Dahili Bilimler Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjective: This study aimed to assess the first-drug efficacy rate in newly diagnosed children with epilepsies treated with antiseizure medications. Methods: This retrospective study was conducted on 1003 children (age range: 3-10 years, and the mean duration of follow-up: 22 +/- 13 months) with newly diagnosed epilepsy. The following parameters were evaluated: first-drug efficacy rate, first-drug-failure rate, and drug resistance rate in the cohort. Results: The first-drug-failure rate was defined in 335/1003 (33%) of the patients, no seizure control in 315 (31%), and drug withdrawal in 20 (2%). There was no significant difference between the group with focal-onset seizures and the group with generalized onset seizures. The first-drug efficacy rate was 67% in children with focal-onset seizures and 66% in children with generalized-onset seizures. Adjunctive antiseizure medication therapy was initiated in 335 patients-dual therapy with 180 patients (18%) and polytherapy with 155 (15%). Drug-resistant epilepsy was defined as 15% in the follow-up period. Etiology-specific diagnoses of the cohort were structural (n = 165, 17%), genetic (n = 25, 3%), metabolic (n = 15%), immune-infectious (n = 17 (2%), and unknown (n = 781, 77%). With a comparison of the 2 most common etiology subgroups (structural versus unknown), a first-drug efficacy rate of 53% and a higher prevalence of drug-resistant epilepsy at 30% were observed in children with structural etiology. First-drug efficacy was statistically lower in children without well-defined epilepsy syndromes (65%) compared with the rate of those with well-defined epilepsy syndrome (79%). Conclusion: This study revealed a first-drug failure rate (33%) in the presented cohort with a drug-resistance epilepsy rate (15%).
dc.identifier.citationGencpinar, P., Arican, P., Olgac Dündar, N., Kilic, B., Sarigecili, E., Okuyaz, C., Aydin, K., & Tekgul, H. (2025). First-drug efficacy and drug-resistant epilepsy rates in children with new-onset epilepsies: A multicenter large cohort study. Journal of Child Neurology, 40(1), 5-9.
dc.identifier.doi10.1177/08830738241283711
dc.identifier.endpage9
dc.identifier.issn0883-0738
dc.identifier.issue1
dc.identifier.pmid39344434
dc.identifier.scopus2-s2.0-85205665225
dc.identifier.scopusqualityQ1
dc.identifier.startpage5
dc.identifier.urihttps://doi.org/10.1177/08830738241283711
dc.identifier.urihttps://hdl.handle.net/11454/117203
dc.identifier.volume40
dc.identifier.wosWOS:001326327400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTekgul, Hasan
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Child Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchildren
dc.subjectefficacy
dc.subjectepilepsy
dc.titleFirst-Drug Efficacy and Drug-Resistant Epilepsy Rates in Children With New-Onset Epilepsies: A Multicenter Large Cohort Study
dc.typeArticle

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