Different approaches for improving skin accumulation of topical corticosteroids

Basit Öğe Kaydı
dc.contributor.authorSenyigit, Taner
dc.contributor.authorPadula, Cristina
dc.contributor.authorOzer, Ozgen
dc.contributor.authorSanti, Patrizia
dc.date.accessioned2019-10-27T21:20:31Z
dc.date.available2019-10-27T21:20:31Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this paper was to evaluate the effect of vehicle, chemical enhancer and iontophoresis on the skin accumulation of clobetasol propionate (CP) and mometasone furoate (MF). In vitro permeation experiments were performed using pig ear skin as barrier and HPLC as quantification method. The formulations tested were chitosan gels, sodium-deoxycholate gels and commercial creams of CP and ME The results obtained indicate that Na-DOC gel had an enhancing effect on the skin accumulation of both active agents. This effect was more evident with CP especially in the stratum corneum and epidermis which are the target sites of topical steroidal treatment. Two terpene derivatives (D-limonene and nerolidol) and Transcutol (R) P were evaluated as chemical penetration enhancers. Nerolidol produced considerable increase in the amount of CP and MF accumulated without any permeation across the skin. The application of electric current (anodal iontophoresis) to the gels improved the accumulation of MF while it did not effect the accumulation of CP. Due to the best accumulation results of nerolidol, the enhancement effect in combination with iontophoresis was also investigated. It was shown that, the combination of anodal iontophoresis and chemical enhancer (nerolidol) produced no further enhancement for both active agents. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Ege UniversityEge University [19/ECZ/2005]; Novartis Drug Companyen_US
dc.description.sponsorshipThe authors wish to thank Research Foundation of Ege University (19/ECZ/2005) and Novartis Drug Company for financial support given to this study.en_US
dc.identifier.doi10.1016/j.ijpharm.2009.07.018en_US
dc.identifier.endpage160en_US
dc.identifier.issn0378-5173
dc.identifier.issue01.Feben_US
dc.identifier.pmid19635541en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2009.07.018
dc.identifier.urihttps://hdl.handle.net/11454/44303
dc.identifier.volume380en_US
dc.identifier.wosWOS:000270495400021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTopical glucocorticoidsen_US
dc.subjectSkin retentionen_US
dc.subjectVehicle effectsen_US
dc.subjectGelen_US
dc.subjectChemical enhancersen_US
dc.subjectIontophoresisen_US
dc.titleDifferent approaches for improving skin accumulation of topical corticosteroidsen_US
dc.typeArticleen_US

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