Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystic ovary syndrome

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dc.contributor.authorKaradeniz, Muammer
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorAyhan, Zengi
dc.contributor.authorYalcin, Murat
dc.contributor.authorOlukman, Murat
dc.contributor.authorCetinkalp, Sevki
dc.contributor.authorAlper, Gulinnaz E.
dc.contributor.authorEroglu, Zuhal
dc.contributor.authorTetik, Asli
dc.contributor.authorCetintas, Vildan
dc.contributor.authorOzgen, Ahmet G.
dc.contributor.authorSaygili, Fusun
dc.contributor.authorYilmaz, Candeger
dc.date.accessioned2019-10-27T21:35:46Z
dc.date.available2019-10-27T21:35:46Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Obesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients. In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study. Results: In PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes. Conclusions: We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.en_US
dc.identifier.doi10.1186/1476-511X-10-193en_US
dc.identifier.issn1476-511X
dc.identifier.pmid22035022en_US
dc.identifier.urihttps://doi.org/10.1186/1476-511X-10-193
dc.identifier.urihttps://hdl.handle.net/11454/45926
dc.identifier.volume10en_US
dc.identifier.wosWOS:000297108800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofLipids in Health and Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the lipid, oxidative stress and homocystein levels in Turkish patients with polycystic ovary syndromeen_US
dc.typeArticleen_US

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