Is it necessary to have routine blood tests in patients treated with isotretinoin?

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dc.contributor.authorErtam, Ilgen
dc.contributor.authorAlper, Sibel
dc.contributor.authorUnal, Idil
dc.date.accessioned2019-10-27T19:20:48Z
dc.date.available2019-10-27T19:20:48Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Several side effects can be observed from isotretinoin use, which has been used in acne therapy for years. In this study, the side effects of isotretinoin on skin and mucosa, blood test changes and their relation with total dose were investigated in patients who used equal doses of isotretinoin. Materials and methods: A total of 91 outpatients with acne vulgaris (57 females and 34 males; age range 17-28 years, mean 21 +/- 2.19 years) were enrolled in this study. Skin and mucosal findings and pre- and post-treatment blood tests and their correlation with the total dose were investigated. Student's t-test and the Mann-Whitney U-test were used in the statistical analyses. Results: In all, 89 out of 91 patients completed the study. Cholesterol (p = 0.00), triglyceride (p = 0.00) and low density lipoprotein (LDL) (p = 0.001) levels were found to be significantly elevated. But these values were not over the double of the upper limits. No correlations were found among the total dose and the skin and mucosal changes as well as the blood test results. Conclusion: It is concluded that examination of cholesterol, triglyceride and LDL-cholesterol should be performed monthly if the initial blood tests are close to the upper limits; otherwise, examinations at 2- or 3-month intervals are sufficient, which would save unnecessary costs.en_US
dc.identifier.doi10.1080/09546630600838359en_US
dc.identifier.endpage216en_US
dc.identifier.issn0954-6634
dc.identifier.issue4en_US
dc.identifier.pmid16971314en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1080/09546630600838359
dc.identifier.urihttps://hdl.handle.net/11454/38915
dc.identifier.volume17en_US
dc.identifier.wosWOS:000240460500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Dermatological Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacneen_US
dc.subjectadverse effectsen_US
dc.subjectblood testsen_US
dc.subjectisotretinoinen_US
dc.subjectskinen_US
dc.titleIs it necessary to have routine blood tests in patients treated with isotretinoin?en_US
dc.typeArticleen_US

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