Apoptosis-mediated Cytotoxic Effects of Ibandronic Acid on Hormone- and Drug-refractory Prostate Cancer Cells and Human Breast Cancer Cells

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dc.contributor.authorKucukzeybek, Y.
dc.contributor.authorGorumlu, G.
dc.contributor.authorCengiz, E.
dc.contributor.authorKarabulut, B.
dc.contributor.authorSezgin, C.
dc.contributor.authorAtmaca, H.
dc.contributor.authorSanli, U. A.
dc.contributor.authorUzunoglu, S.
dc.contributor.authorUslu, R.
dc.date.accessioned2019-10-27T21:15:15Z
dc.date.available2019-10-27T21:15:15Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractOver 80% of patients with advanced breast and prostate cancer ultimately develop bone metastases. Ibandronic acid has proven efficacy for treatment of bone metastasis secondary to breast cancer. This study was designed to investigate the cytotoxic and apoptotic effects of ibandronic acid on hormone- and drug-refractory prostate carcinoma DU-145 and human breast cancer MCF-7 cell lines. Cytotoxicity was evaluated using an XTT cell proliferation kit, and apoptosis was assessed by enzyme-linked immunosorbent assay (histone-DNA fragmentation) and measurement of caspase 3/7 activity. With increasing concentrations of ibandronic acid there was a dose- and time-dependent decrease in cell numbers. MCF-7 cells were more resistant than DU-145 cells (half maximal inhibitory concentrations of 122 and 90 mu M, respectively). Ibandronic acid induced apoptosis in both cell lines. The study showed an apoptosis-mediated cytotoxic effect for ibandronic acid (in addition to the already known osteoclast inhibiting effect) in breast cancer patients with bone metastases; which was also observed in prostate cancer cells. Further clinical studies involving breast and prostate cancer patients with bone metastases are warranted to confirm these findings.en_US
dc.identifier.doi10.1177/147323001003800511en_US
dc.identifier.endpage1672en_US
dc.identifier.issn0300-0605
dc.identifier.issue5en_US
dc.identifier.pmid21309480en_US
dc.identifier.startpage1663en_US
dc.identifier.urihttps://doi.org/10.1177/147323001003800511
dc.identifier.urihttps://hdl.handle.net/11454/43504
dc.identifier.volume38en_US
dc.identifier.wosWOS:000285404000011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIBANDRONIC ACIDen_US
dc.subjectBISPHOSPHONATESen_US
dc.subjectBREAST CANCERen_US
dc.subjectPROSTATE CANCERen_US
dc.subjectCYTOTOXICITYen_US
dc.subjectAPOPTOSISen_US
dc.titleApoptosis-mediated Cytotoxic Effects of Ibandronic Acid on Hormone- and Drug-refractory Prostate Cancer Cells and Human Breast Cancer Cellsen_US
dc.typeArticleen_US

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