Effects of a beta-blocker on ventricular late potentials in patients with acute-anterior myocardial infarction receiving successful thrombolytic therapy

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dc.contributor.authorEvrengul, H
dc.contributor.authorDursunoglu, D
dc.contributor.authorKayikcioglu, M
dc.contributor.authorCan, L
dc.contributor.authorTanriverdi, H
dc.contributor.authorKaftan, A
dc.contributor.authorKilic, M
dc.date.accessioned2019-10-27T18:37:29Z
dc.date.available2019-10-27T18:37:29Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractLate potentials (LP) detected on the signal-averaged electrocardiogram (SAECG) predict arrhythmic events after acute myocardial infarction (AMI). It is also well established that successful thrombolytic therapy reduces the incidence of LP. Our aim was to evaluate the effects of a beta-blocker on LP in patients receiving thrombolytic therapy. We Studied 40 patients presenting with anteroseptal AMI (< 6 hours). All patients received thrombolytic therapy and were evaluated with coronary angiography at predischarge. Eighteen patients received metoprolol (5 mg IV on admission followed by 50 mg BID). SAECG recordings were obtained serially using an ART system (40-250 Hz filter, noise < 0.5 mV) prior to thrombolytic therapy, after 48 hours and after 10 days. LP was defined as positive if the SAECG met at least 2 of the Gomes criteria. Changes observed in SAECG recordings after thrombolytic therapy were correlated with angiographic and clinical data with regard to the usage of BB. The frequencies of LP before and after thrombolytic therapy were compared with the McNemar test. There were no significant differences between the clinical characteristics, risk factors, and angiographic findings (including infarct related artery patency and LV functions) of the groups. Baseline SAECG findings were also similar between the groups. The incidence of LP significantly decreased after TT in the BB group, however, this change was not observed in patients who did not receive BB (P = 0.012, McNemar test). Beta-blockers reduce the incidence of LPs following thrombolytic therapy in patients with anterior AMI. This might be explained by the possible beneficial effect of BB on the arrhythmogenic substrate.en_US
dc.identifier.doi10.1536/jhj.45.11en_US
dc.identifier.endpage21en_US
dc.identifier.issn0021-4868
dc.identifier.issue1en_US
dc.identifier.pmid14973346en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1536/jhj.45.11
dc.identifier.urihttps://hdl.handle.net/11454/36414
dc.identifier.volume45en_US
dc.identifier.wosWOS:000220464100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Heart Journal Assocen_US
dc.relation.ispartofJapanese Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlate potentialen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectsignal-averaged electrocardiographyen_US
dc.subjectbeta-blockeren_US
dc.titleEffects of a beta-blocker on ventricular late potentials in patients with acute-anterior myocardial infarction receiving successful thrombolytic therapyen_US
dc.typeArticleen_US

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