Therapeutic plasma exchange in hypertriglyceridemic patients

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dc.contributor.authorSimsir, Ilgm Yildirim
dc.contributor.authorSoyaltin, Utku Erdem
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorCetinicalp, Sevki
dc.contributor.authorSaygili, Fusun
dc.contributor.authorDonmez, Ayhan
dc.contributor.authorOzgen, Ahmet Gokhan
dc.date.accessioned2019-10-27T09:47:54Z
dc.date.available2019-10-27T09:47:54Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined. Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center. Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 2-2, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 +/- 1472 mg/dL) than the mean TG level afterwards (948 +/- 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE. Conclusion: TPE is a safe, fast, and effective treatment modality in experienced centers.en_US
dc.identifier.doi10.3906/sag-1811-105en_US
dc.identifier.endpage878en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid31203594en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage872en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1811-105
dc.identifier.urihttps://hdl.handle.net/11454/29457
dc.identifier.volume49en_US
dc.identifier.wosWOS:000471902200025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypertriglyceridemiaen_US
dc.subjectpancreatitisen_US
dc.subjectapheresisen_US
dc.subjecttherapeutic plasma exchangeen_US
dc.subjectfresh frozen plasmaen_US
dc.titleTherapeutic plasma exchange in hypertriglyceridemic patientsen_US
dc.typeArticleen_US

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