Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients

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dc.contributor.authorTunc S.E.
dc.contributor.authorAksu K.
dc.contributor.authorKeser G.
dc.contributor.authorOksel F.
dc.contributor.authorDoganavsargil E.
dc.contributor.authorPirildar T.
dc.contributor.authorTurk T.
dc.contributor.authorTerzioglu E.
dc.contributor.authorHuseyinov A.
dc.date.accessioned2019-10-27T08:59:18Z
dc.date.available2019-10-27T08:59:18Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to compare plasma Platelet-activating factor (PAF) and P-selectin (CD62P) activities in Behçet's disease patients with and without thrombosis. Methods: In this cross-sectional and descriptive study, 30 consecutive Behçet's patients were included, 15 of them with venous thrombosis. All patients were also divided into two subgroups according to the presence or absence of clinical activity. Plasma PAF levels, basal and Ca++ ionophore (A23187)-induced leukocyte (cellular) PAF activities, and platelet-rich plasma ?CD62P activity (the mean fluorescent density difference between CD62P phycoerythrin-positive and -negative stains) were evaluated. Results: In the thrombotic group, plasma PAF (P=0.001), basal leukocyte PAF (P=0.017), induced leukocyte PAF (P=0.024), and ?CD62P (P=0.023) levels were significantly higher than in the nonthrombotic group. In the whole group of Behçet's patients, there was a positive correlation between plasma PAF and ?CD62P levels (r=0.533, P=0.002). When we compared clinically active and inactive patients with respect to the above parameters, there was no significant difference, irrespective of thrombosis. Plasma PAF (P=0.001), basal leukocyte PAF (P=0.004), and ?CD62P (P=0.038) levels were significantly higher in the presence of both clinical activity and thrombosis than of clinical activity alone. Conclusion: Platelet-activating factor and CD62P may contribute to endothelial injury and thrombosis development in Behçet's disease. These two parameters seem related to the presence of thrombosis rather than clinical activity. © Springer-Verlag 2004.en_US
dc.identifier.doi10.1007/s00296-004-0450-4en_US
dc.identifier.endpage331en_US
dc.identifier.issn0172-8172
dc.identifier.issue5en_US
dc.identifier.pmid15004723en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-004-0450-4
dc.identifier.urihttps://hdl.handle.net/11454/27756
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehçet's diseaseen_US
dc.subjectP-selectinen_US
dc.subjectPlatelet-activating factoren_US
dc.subjectThrombosisen_US
dc.titlePlatelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patientsen_US
dc.typeArticleen_US

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