Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation

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dc.authorscopusid24172536600
dc.authorscopusid57226416801
dc.authorscopusid57226424418
dc.authorscopusid57201362301
dc.authorscopusid8633854100
dc.authorscopusid57216800466
dc.authorscopusid6603594798
dc.authorwosidKUŞAT, KEVSER/AAB-9366-2022
dc.authorwosidAkgöl, Sinan/GON-7749-2022
dc.authorwosidtekin, volkan/AEE-4731-2022
dc.contributor.authorAvcibasi, Ugur
dc.contributor.authorTurkyarar, Taner
dc.contributor.authorKaradag, Aysegul
dc.contributor.authorBakan, Buket
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.contributor.authorKusat, Kevser
dc.contributor.authorAkgol, Sinan
dc.date.accessioned2023-01-12T19:50:42Z
dc.date.available2023-01-12T19:50:42Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractThe aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.en_US
dc.description.sponsorshipManisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) [2017-016]en_US
dc.description.sponsorshipThe authors are thankful for the financial support from the Manisa Celal Bayar University Coordination Unit of Scientific Research Projects (BAP) (Project number: 2017-016). We thank to Buket Ate for the technical assistance during the animal experiments. We also thank Norma R. de Yagcier and Mahdi Rajabimovahed for reviewing our study as native English speakers.en_US
dc.identifier.doi10.1007/s10967-021-07817-6
dc.identifier.endpage525en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85111514580en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-021-07817-6
dc.identifier.urihttps://hdl.handle.net/11454/76152
dc.identifier.volume329en_US
dc.identifier.wosWOS:000664014000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Radioanalytical And Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNanopolymeren_US
dc.subjectGraft Polymeren_US
dc.subjectCytotoxicityen_US
dc.subjectTc-99men_US
dc.subjectRadiolabelingen_US
dc.subjectProlineen_US
dc.subjectMagnetic Nanoparticlesen_US
dc.subjectToxicityen_US
dc.subjectBiodistributionen_US
dc.subjectCytotoxicityen_US
dc.subjectAdsorptionen_US
dc.subjectDeliveryen_US
dc.subjectProlineen_US
dc.subjectTherapyen_US
dc.subjectFutureen_US
dc.subjectSizeen_US
dc.titlePreparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluationen_US
dc.typeArticleen_US

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