Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.
Açıklama
Anahtar Kelimeler
Nanopolymer, Graft Polymer, Cytotoxicity, Tc-99m, Radiolabeling, Proline, Magnetic Nanoparticles, Toxicity, Biodistribution, Cytotoxicity, Adsorption, Delivery, Proline, Therapy, Future, Size
Kaynak
Journal Of Radioanalytical And Nuclear Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
329
Sayı
2
