Application of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challenges

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dc.contributor.authorShademan, Behrouz
dc.contributor.authorBiray Avci, Cigir
dc.contributor.authorNikanfar, Masoud
dc.contributor.authorNourazarian, Alireza
dc.date.accessioned2020-12-01T12:01:18Z
dc.date.available2020-12-01T12:01:18Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractGenetic factors (gene mutations) lead to various rare and prevalent neurological diseases. Identification of underlying mutations in neurodegenerative diseases is of paramount importance due to the heterogeneous nature of the genome and different clinical manifestations. An early and accurate molecular diagnosis are cardinal for neurodegenerative patients to undergo proper therapeutic regimens. the next-generation sequencing (NGS) method examines up to millions of sequences at a time. As a result, the rare molecular diagnoses, previously presented with "unknown causes", are now possible in a short time. This method generates a large amount of data that can be utilized in patient management. Since each person has a unique genome, the NGS has transformed diagnostic and therapeutic strategies into sequencing and individual genomic mapping. However, this method has disadvantages like other diagnostic methods. Therefore, in this review, we aimed to briefly summarize the NGS method and correlated studies to unravel the genetic causes of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, epilepsy, and MS. Finally, we discuss the NGS challenges and opportunities in neurodegenerative diseases.en_US
dc.identifier.doi10.1007/s12017-020-08601-7en_US
dc.identifier.issn1535-1084
dc.identifier.issn1559-1174
dc.identifier.pmid32399804en_US
dc.identifier.scopus2-s2.0-85084567347en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s12017-020-08601-7
dc.identifier.urihttps://hdl.handle.net/11454/62387
dc.identifier.wosWOS:000532101700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofNeuromolecular Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGene panelen_US
dc.subjectNeurological diseasesen_US
dc.subjectNext-generation sequencing (NGS)en_US
dc.subjectWhole exome sequencing (WES)en_US
dc.subjectWhole genome sequencing (WGS)en_US
dc.titleApplication of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challengesen_US
dc.typeReview Articleen_US

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