Endocarditis-TR: Diagnosis, treatment, and prognosis of the infective endocarditis patients admitting tertiary centres of Turkey

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dc.authorscopusid37099642500
dc.authorscopusid55751604100
dc.authorscopusid56719330400
dc.authorscopusid35361468300
dc.authorscopusid57217681171
dc.authorscopusid57464741000
dc.authorscopusid53983731100
dc.contributor.authorÇalik A.N.
dc.contributor.authorÖzlük Ö.A.
dc.contributor.authorKarataş M.B.
dc.contributor.authorÇanga Y.
dc.contributor.authorEren S.
dc.contributor.authorAyhan G.
dc.contributor.authorAkdeniz A.
dc.date.accessioned2023-01-12T20:26:14Z
dc.date.available2023-01-12T20:26:14Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground/aim: Infective endocarditis (IE) is still a significant cause of morbidity and mortality among cardiovascular diseases. ENDOCARDITIS-TR study aims to evaluate the compliance of the diagnostic and therapeutic methods being used in Turkey with current guidelines. Materials and methods: The ENDOCARDITIS-TR trial is a multicentre, prospective, observational study consisting of patients admitted to tertiary centres with a definite diagnose of IE. In addition to the demographic, clinical, microbiological, and echocardiographic findings of the patients, adverse events, indications for surgery, and in-hospital mortality were recorded during a 2-year time interval. Results: A total of 208 IE patients from 7 tertiary centres in Turkey were enrolled in the study. The study population included 125 (60.1%) native valve IE (NVE), 65 (31.3%) prosthetic IE (PVIE), and 18 (8.7%) intracardiac device-related IE (CDRIE). One hundred thirty-five patients (64.9%) were culture positive, and the most frequent pathogenic agent was methicillin-susceptible Staphylococcus aureus (MSSA) (18.3%). Among 155 (74.5%) patients with an indication for surgery, only 87 (56.1%) patients underwent surgery. The all-cause mortality rate was 29.3% in-hospital follow-up. Multivariable Cox regression analysis revealed that absence of surgery when indicated (HR: 3.29 95% CI: 0.93–11.64 p = 0.05), albumin level at admission (HR: 0.46 95% CI: 0.29–0.73 P < 0.01), abscess formation (HR: 2.11 95% CI: 1.01–4.38 p = 0.04) and systemic embolism (HR: 1.78 95% CI: 1.05–3.02 p = 0.03) were ascertained independent predictors of in-hospital all-cause mortality. Conclusion: The short-term results of the ENDOCARDITIS-TR trial showed the high frequency of staphylococcal IE, relatively high in-hospital mortality rates, shortage of surgical treatment despite guideline-based surgical indications and low usage of novel imaging techniques. The results of this study will provide a better insight to physicians in respect to their adherence to clinical practice guidelines. © TÜBİTAK.en_US
dc.identifier.doi10.3906/sag-2105-118
dc.identifier.endpage455en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.pmid36161622en_US
dc.identifier.scopus2-s2.0-85129027294en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2105-118
dc.identifier.urihttps://hdl.handle.net/11454/79945
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectheart valve diseaseen_US
dc.subjectin-hospital mortalityen_US
dc.subjectInfective endocarditisen_US
dc.subjectabscessen_US
dc.subjectadulten_US
dc.subjectalbumin levelen_US
dc.subjectall cause mortalityen_US
dc.subjectArticleen_US
dc.subjectbacterial endocarditisen_US
dc.subjectbacterium cultureen_US
dc.subjectblood samplingen_US
dc.subjectclinical trialen_US
dc.subjectcomputer assisted tomographyen_US
dc.subjectechocardiographyen_US
dc.subjectembolismen_US
dc.subjectfemaleen_US
dc.subjectfollow upen_US
dc.subjectheart failureen_US
dc.subjectheart surgeryen_US
dc.subjecthospital admissionen_US
dc.subjecthumanen_US
dc.subjectin-hospital mortalityen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmethicillin susceptible Staphylococcus aureusen_US
dc.subjectmortality rateen_US
dc.subjectmulticenter studyen_US
dc.subjectobservational studyen_US
dc.subjecttherapy effecten_US
dc.subjecttransesophageal echocardiographyen_US
dc.subjecttransthoracic echocardiographyen_US
dc.titleEndocarditis-TR: Diagnosis, treatment, and prognosis of the infective endocarditis patients admitting tertiary centres of Turkeyen_US
dc.typeArticleen_US

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