Comparison of Culture-Positive and -Negative Microbial Keratitis

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dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authoridSELVER, OZLEM BARUT/0000-0003-3333-3349
dc.authoridHilmioglu Polat, Suleyha/0000-0001-8850-2715
dc.authoridEgrilmez, Sait/0000-0002-6971-527X
dc.authoridAydemir, Sabire Sohret/0000-0001-8354-9100
dc.authorscopusid57225917267
dc.authorscopusid24077472700
dc.authorscopusid23989747000
dc.authorscopusid6602843026
dc.authorscopusid8905840200
dc.authorscopusid56088640300
dc.authorscopusid7003943383
dc.authorwosidPalamar, Melis/H-5903-2013
dc.authorwosidSELVER, OZLEM BARUT/N-5108-2019
dc.authorwosidEgrilmez, Sait/P-7923-2015
dc.contributor.authorYarimada, Semir
dc.contributor.authorSelver, Ozlem Barut
dc.contributor.authorPalamar, Melis
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorAydemir, Sabire Sohret
dc.contributor.authorPolat, Suleyha Hilmioglu
dc.contributor.authorYagci, Ayse
dc.date.accessioned2023-01-12T20:16:56Z
dc.date.available2023-01-12T20:16:56Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives: To evaluate and compare the risk factors, presenting features, and outcomes of patients with culture-positive and culture-negative microbial keratitis (MK) who presented to a tertiary referral center. Materials and Methods: We conducted a retrospective review of the medical records of 314 patients who were diagnosed with MK in our clinic between 2012 and 2019. Results: Among 314 patients, 142 had positive cultures (45.2%). The mean ages of the culture-positive and-negative patients at the time of diagnosis were 51.39 +/- 21.31 (range, 14-90) years and 56.68 +/- 21.34 (7-94) years, respectively (p=0.028). The mean best corrected visual acuity (BCVA) of the culture-positive and-negative patients were1.74 +/- 1.25 (0-3.1) LogMAR and 1.91 +/- 1.23 (0-3.1) LogMAR prior to treatment and increased to 1.21 +/- 1.30 (0-3.1) LogMAR and 1.27 +/- 1.29 (0-3.1) LogMAR at last visit, respectively. There was no statistically significant difference between culture-positive and-negative patients' BCVA levels at presentation or last visit. Ninety-two patients (64.7%) were infected with bacteria and 50 patients (35.2%) with fungi. The most common pathogen was Pseudomonas aeruginosa (18.3%), followed by Streptococcus pneumoniae (11.2%) and Fusarium spp. (11.2%). Keratitis foci were either centrally or paracentrally located in 105 eyes (73.9%) of culture-positive patients and 149 eyes (86.6%) of culture-negative patients. Multiple foci were present mostly in culture-positive patients (p=0.001). There was no significant difference between the culture-positive and-negative groups in terms of hypopyon presence (p=0.364). The proportion of contact lens (CL) wearers was 33% (n=47) among culture-positive MK patients and 13.3% (n=23) among culture-negative MK patients, respectively (p<0.001). Culture positivity was found to be significantly higher in keratitis associated with CL use (p=0.0001). Conclusion: Microbiological analysis and culture evaluation are important steps in order to manage proper treatment in microbial keratitis. Prognosis mostly depends on the infectivity of the microbiological agent.en_US
dc.identifier.doi10.4274/tjo.galenos.2021.98046
dc.identifier.endpage5en_US
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue1en_US
dc.identifier.pmid35196833en_US
dc.identifier.scopus2-s2.0-85125214149en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.galenos.2021.98046
dc.identifier.urihttps://hdl.handle.net/11454/78794
dc.identifier.volume52en_US
dc.identifier.wosWOS:000761159800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Ophthalmological Socen_US
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectContact lensen_US
dc.subjectcultureen_US
dc.subjectmicrobial keratitisen_US
dc.subjectBacterial Keratitisen_US
dc.subjectPredisposing Factorsen_US
dc.subjectReferral Centeren_US
dc.subjectRisk-Factorsen_US
dc.subjectExperienceen_US
dc.subjectDiagnosisen_US
dc.subjectFeaturesen_US
dc.titleComparison of Culture-Positive and -Negative Microbial Keratitisen_US
dc.typeArticleen_US

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