The Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulins

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dc.authorscopusid56030917500
dc.authorscopusid57665248400
dc.authorscopusid56549895700
dc.contributor.authorPeskersoy C.
dc.contributor.authorOguzhan A.
dc.contributor.authorGurlek O.
dc.date.accessioned2023-01-12T20:23:31Z
dc.date.available2023-01-12T20:23:31Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective. This study investigated the effects of flowable resin composites (FCR) on the restoration of noncarious cervical lesions (NCCL) and their impact on periodontal tissues. Materials and Methods. 30 periodontally healthy patients were assigned into three groups randomly; group VF: self-adhering FCR, group NF: fluoride-releasing FCR, and group SF: microhybrid FCR. Gingival crevicular fluid (GCF) volume levels of osteoprotegerin (OPG), immunoglobulins (IgA, IgM), and interleukins (IL-1, IL-1?, and IL-10) in GCF were analyzed with ELISA tests. Clinical success rates were evaluated using USPHS criteria during the 12-month follow-up. Results. The GCF volume was increased mostly in group SF (1.34±0.09 ?l). While the titer of interleukin was increased in all groups, higher increases were observed in IL-1 and IL-1? in group NF (170.78 pg/ml and 39.35 pg/ml). Increased IL-10 was observed in group VF (14.33±0.85 pg/ml). IgA levels varied partially among all groups (p>0.05), and even IgM levels were elevated immediately after the restoration process but returned to normal on the 28th day (p<0.05). Group NF failed in most of the USPHS criteria, while the material group VF and group SF presented acceptable results except in the marginal adaptation criterion (p<0.05). Conclusions. Clinical efficacy of self-adhering FCR was found the best for restoration of NCCL while fluoride-releasing FCR stimulated the periodontal response and had negative effects on GCF volume, cytokine, and immunoglobulin levels. © 2022 Cem Peskersoy et al.en_US
dc.identifier.doi10.1155/2022/6476597
dc.identifier.issn2314-6133
dc.identifier.pmid35502340en_US
dc.identifier.scopus2-s2.0-85129405312en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1155/2022/6476597
dc.identifier.urihttps://hdl.handle.net/11454/79721
dc.identifier.volume2022en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofBioMed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcytokineen_US
dc.subjectdentin bonding agenten_US
dc.subjectflowable composite resinen_US
dc.subjectfluorideen_US
dc.subjectimmunoglobulinen_US
dc.subjectimmunoglobulin Aen_US
dc.subjectimmunoglobulin Men_US
dc.subjectinterleukin 1en_US
dc.subjectinterleukin 10en_US
dc.subjectinterleukin 1betaen_US
dc.subjectosteoprotegerinen_US
dc.subjectphosphoric aciden_US
dc.subjectresinen_US
dc.subjectunclassified drugen_US
dc.subjectcytokineen_US
dc.subjectflowable hybrid compositeen_US
dc.subjectimmunoglobulin Aen_US
dc.subjectimmunoglobulin Men_US
dc.subjectinterleukin 10en_US
dc.subjectinterleukin derivativeen_US
dc.subjectplant resinen_US
dc.subjectresinen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectclinical articleen_US
dc.subjectclinical examinationen_US
dc.subjectcontrolled studyen_US
dc.subjectdental etchingen_US
dc.subjectdental healthen_US
dc.subjectdental restorationen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjectgingivitisen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectperiodontal diseaseen_US
dc.subjectperiodontiumen_US
dc.subjectrandomized controlled trialen_US
dc.subjectComposite Resinsen_US
dc.subjectCytokinesen_US
dc.subjectFluoridesen_US
dc.subjectHumansen_US
dc.subjectImmunoglobulin Aen_US
dc.subjectImmunoglobulin Men_US
dc.subjectInterleukin-10en_US
dc.subjectInterleukinsen_US
dc.subjectResins, Planten_US
dc.titleThe Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulinsen_US
dc.typeArticleen_US

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